Academic Journal
Tracking the turnover of SARS-CoV-2 VOCs Gamma to Delta in a Brazilian state (Minas Gerais) with a high-vaccination status
| العنوان: | Tracking the turnover of SARS-CoV-2 VOCs Gamma to Delta in a Brazilian state (Minas Gerais) with a high-vaccination status |
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| المؤلفون: | Fonseca, Paula L C, Moreira, Filipe R R, de Souza, Rafael M, Guimarães, Natália R, Carvalho, Nara O, Adelino, Talita E R, Alves, Hugo J, Alvim, Luige B, Candido, Darlan S, Coelho, Helena P, Costa, Alana V B, Costa, Walyson C, de Carvalho, Alex F, de Faria, Bruna W F, de Lima, Aline B, de Oliveira, Eneida S, de Souza, Carolina S A, de Souza, Fernanda G, Dias, Rillery C, Geddes, Victor E V, Godinho, Igor P, Gonçalves, Alessandro L, Lourenço, Karine L, Magalhães, Rubens D M, Malta, Frederico S V, Medeiros, Eva L A, Mendes, Fernanda S, Mendes, Pedro H B de P, Mendonça, Cristiane P T B, Menezes, Andre L, Menezes, Diego, Menezes, Mariane T, Miguita, Lucyene, Moreira, Rennan G, Peixoto, Renata B, Queiroz, Daniel C, Ribeiro, Adriana A, Ribeiro, Ana Paula de B, Saliba, Juliana W, Sato, Hugo I, Silva, Joice do P, Silva, Natiely P, Faria, Nuno R, Teixeira, Santuza M R, da Fonseca, Flávio G, Fernandes, Ana Paula S M, Zauli, Danielle A G, Januario, José Nélio, de Oliveira, Jaqueline S, Iani, Felipe C de M |
| المساهمون: | Fundação de Amparo à Pesquisa do Estado de São Paulo, MEC/CAPES, Fundação de Amparo à Pesquisa do Estado de Minas Gerais, Medical Research Council-São Paulo Research Foundation (FAPESP) CADDE partnership award, Bill and Melinda Gates Foundation, Wellcome Trust and the Royal Society, Rede Corona-ômica BR MCTI/FINEP affiliated to 116 RedeVírus/MCTI, Financiadora de Estudos e Projetos, Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro, Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| المصدر: | Virus Evolution ; volume 8, issue 2 ; ISSN 2057-1577 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2022 |
| الوصف: | The emergence and global dissemination of Severe Acute Respiratory Syndrome virus 2 (SARS-CoV-2) variants of concern (VOCs) have been described as the main factor driving the Coronavirus Disease 2019 pandemic. In Brazil, the Gamma variant dominated the epidemiological scenario during the first period of 2021. Many Brazilian regions detected the Delta variant after its first description and documented its spread. To monitor the introduction and spread of VOC Delta, we performed Polymerase Chain Reaction (PCR) genotyping and genome sequencing in ten regional sentinel units from June to October 2021 in the State of Minas Gerais (MG). We documented the introduction and spread of Delta, comprising 70 per cent of the cases 8 weeks later. Comparing the viral loads of the Gamma and Delta dominance periods, we provide additional evidence that the latter is more transmissible. The spread and dominance of Delta did not culminate in the increase in cases and deaths, suggesting that the vaccination may have restrained the epidemic growth. Analysis of 224 novel Delta genomes revealed that Rio de Janeiro state was the primary source for disseminating this variant in the state of MG. We present the establishment of Delta, providing evidence of its enhanced transmissibility and showing that this variant shift did not aggravate the epidemiological scenario in a high immunity setting. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/ve/veac064 |
| DOI: | 10.1093/ve/veac064/45095859/veac064.pdf |
| الاتاحة: | http://dx.doi.org/10.1093/ve/veac064 https://academic.oup.com/ve/advance-article-pdf/doi/10.1093/ve/veac064/45095859/veac064.pdf https://academic.oup.com/ve/article-pdf/8/2/veac064/47902049/veac064.pdf |
| Rights: | https://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.FD7E250F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ve/veac064 |
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