Academic Journal
Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock.
| العنوان: | Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock. |
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| المؤلفون: | Dyar KA, Ciciliot S, Wright LE, Biensø RS, Tagliazucchi GM, Patel VR, Paz MI, Gudiksen A, Solagna F, Albiero M, Moretti I, Eckel Mahan KL, Baldi P, Sassone Corsi P, Rizzuto R, Pilegaard H, Blaauw B, Schiaffino S., FORCATO, Mattia, BICCIATO, Silvio |
| المساهمون: | Dyar, Ka, Ciciliot, S, Wright, Le, Biensø, R, Tagliazucchi, Gm, Patel, Vr, Forcato, Mattia, Paz, Mi, Gudiksen, A, Solagna, F, Albiero, M, Moretti, I, Eckel Mahan, Kl, Baldi, P, Sassone Corsi, P, Rizzuto, R, Bicciato, Silvio, Pilegaard, H, Blaauw, B, Schiaffino, S. |
| سنة النشر: | 2014 |
| المجموعة: | Archivio della ricerca dell'Università di Modena e Reggio Emilia (Unimore: IRIS) |
| مصطلحات موضوعية: | Bmal1, Circadian rhythm, Glucose metabolism, Glucose uptake, Muscle insulin resistance, Skeletal muscle |
| الوصف: | Circadian rhythms control metabolism and energy homeostasis, but the role of the skeletal muscle clock has never been explored. We generated conditional and inducible mouse lines with muscle-specific ablation of the core clock gene Bmal1. Skeletal muscles from these mice showed impaired insulin-stimulated glucose uptake with reduced protein levels of GLUT4, the insulin-dependent glucose transporter, and TBC1D1, a Rab-GTPase involved in GLUT4 translocation. Pyruvate dehydrogenase (PDH) activity was also reduced due to altered expression of circadian genes Pdk4 and Pdp1, coding for PDH kinase and phosphatase, respectively. PDH inhibition leads to reduced glucose oxidation and diversion of glycolytic intermediates to alternative metabolic pathways, as revealed by metabolome analysis. The impaired glucose metabolism induced by muscle-specific Bmal1 knockout suggests that a major physiological role of the muscle clock is to prepare for the transition from the rest/fasting phase to the active/feeding phase, when glucose becomes the predominant fuel for skeletal muscle |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/24567902; info:eu-repo/semantics/altIdentifier/wos/WOS:000209638000005; volume:3; issue:1; firstpage:29; lastpage:41; journal:MOLECULAR METABOLISM; http://hdl.handle.net/11380/1013125; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84895128336 |
| DOI: | 10.1016/j.molmet.2013.10.005 |
| الاتاحة: | http://hdl.handle.net/11380/1013125 https://doi.org/10.1016/j.molmet.2013.10.005 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.FD74997C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.molmet.2013.10.005 |
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