Academic Journal
Transanal irrigation is a better choice for bowel dysfunction in adults with spina bifida: a randomized controlled trial
| العنوان: | Transanal irrigation is a better choice for bowel dysfunction in adults with spina bifida: a randomized controlled trial |
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| المؤلفون: | Brochard, Charlène, Jezequel, Magali, Blanchard-Dauphin, Anne, Kerdraon, Jacques, Perrouin-Verbe, Brigitte, Leroi, Anne‐marie, Reymann, Jean Michel, Peyronnet, Benoît, Morçet, Jeff, Siproudhis, Laurent |
| المساهمون: | Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Ponchaillou, The Enteric Nervous System in gut and brain disorders U1235 (TENS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), Centre Mutualiste de Rééducation et de Réadaptation Fonctionnelles de KERPAPE Ploemeur (CMRRF), Centre Mutualiste de Rééducation et de Réadaptation Fonctionnelles de Kerpape, Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes), Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de Physiologie Digestive, Urinaire, Respiratoire et de l'Exercice CHU Rouen, Hôpital Charles Nicolle Rouen, CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Centre d'Investigation Clinique Rennes (CIC), Université de Rennes (UR)-Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Ponchaillou -Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'urologie Rennes = Urology Rennes, Service des Maladies de l'Appareil Digestif CHU Rennes, Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), French Ministry of Health. Grant Number: 2013-A01520-45 |
| المصدر: | ISSN: 1462-8910. |
| بيانات النشر: | HAL CCSD Wiley |
| سنة النشر: | 2023 |
| المجموعة: | Université de Rennes 1: Publications scientifiques (HAL) |
| مصطلحات موضوعية: | Spina bifida, bowel dysfunction, conservative treatment, faecal incontinence, randomised controlled trial, transanal irrigation, [SDV]Life Sciences [q-bio], [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology |
| الوصف: | International audience ; Aim: To compare transanal irrigation with conservative bowel management for the treatment of bowel dysfunction in Spina bifida (SB) patients.Methods: Patients with SB and bowel dysfunction were randomly assigned to receive either transanal irrigation or conservative bowel management. The effectiveness of the treatment was defined as a decrease of 4 points in the neurogenic bowel dysfunction (NBD) score at week 10. Data on incontinence (Cleveland scores; Jorge-Wexner [JW]) and constipation (Knowles-Eccersley-Scott Symptom Constipation Score [KESS]) were recorded at 10 and 24 weeks after inclusion. Data were analysed on an intention-to-treat basis.Results: A total of 34 patients were randomised: 16 patients to conservative bowel management and 18 patients to transanal irrigation. A total of 19/31 (61%) patients improved at week 10, 13 (76%) in the transanal irrigation group versus six (43%) in the conservative group (p = 0.056). In the irrigation group, the decrease in NBD score was -6.9 (-9.9 to -4.02) versus -1.9 (-6.5 to -2.8) in the conservative group (p = 0.049 in univariate and p = 0.004 in multivariate analysis). The NBD, Cleveland (JW and KESS) and Rosenberg scores were significantly lower in the transanal irrigation group than in the conservative bowel management group at week 10.Conclusions: This prospective, randomised, controlled, multicentre study in adult patients with SB suggests that transanal irrigation may be more effective than conservative bowel management. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/36799340; hal-04008711; https://normandie-univ.hal.science/hal-04008711; https://normandie-univ.hal.science/hal-04008711/document; https://normandie-univ.hal.science/hal-04008711/file/Brochard%20et%20al.%20-%202023%20-%20Transanal%20irrigation%20is%20a%20better%20choice%20for%20bowel%20.pdf; PUBMED: 36799340 |
| DOI: | 10.1111/codi.16518 |
| الاتاحة: | https://normandie-univ.hal.science/hal-04008711 https://normandie-univ.hal.science/hal-04008711/document https://normandie-univ.hal.science/hal-04008711/file/Brochard%20et%20al.%20-%202023%20-%20Transanal%20irrigation%20is%20a%20better%20choice%20for%20bowel%20.pdf https://doi.org/10.1111/codi.16518 |
| Rights: | http://creativecommons.org/licenses/by-nc/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.FD49B530 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/codi.16518 |
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