Differences in Antiphospholipid Antibody Profile between Patients with Obstetric and Thrombotic Antiphospholipid Syndrome

التفاصيل البيبلوغرافية
العنوان:	Differences in Antiphospholipid Antibody Profile between Patients with Obstetric and Thrombotic Antiphospholipid Syndrome
المؤلفون:	Anunciacion Llunell, Ariadna, Muñoz Muñoz, Candido, Roggenbuck, Dirk, Frasca, Stefano, Pardos Gea, José, Alijotas Reig, Jaume, Miro Mur, Francesc, Esteve-Valverde, Enrique
المساهمون:	Institut Català de la Salut, Anunciación-Llunell A, Miró-Mur F Àrea de Malalties Autoimmunes Sistèmiques, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Muñoz C Centre for Rheumatology Research, University College of London, London, UK. Roggenbuck D Faculty of Health Sciences Brandenburg, Brandenburg University of Technology Cottbus-Senftenberg, Senftenberg, Germany. GA Generic Assays GmbH, Dahlewitz, Germany. Frasca S GA Generic Assays GmbH, Dahlewitz, Germany. Pardos-Gea J Àrea de Malalties Autoimmunes Sistèmiques, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Àrea de Malalties Autoimmunes Sistèmiques, Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Esteve-Valverde E Systemic Autoimmune Diseases Unit, Department of Internal Medicine, Hospital Universitari Parc Taulí, Sabadell, Spain. Alijotas-Reig J Àrea de Malalties Autoimmunes Sistèmiques, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Àrea de Malalties Autoimmunes Sistèmiques, Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Departament de Medicina, Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain, Vall d'Hebron Barcelona Hospital Campus
المصدر:	Scientia
بيانات النشر:	MDPI
سنة النشر:	2022
مصطلحات موضوعية:	Trombosi, Embaràs, Síndrome antifosfolipídica, Autoanticossos, DISEASES::Immune System Diseases::Autoimmune Diseases::Antiphospholipid Syndrome, CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Autoantibodies::Antibodies, Antiphospholipid, DISEASES::Cardiovascular Diseases::Vascular Diseases::Embolism and Thrombosis::Thrombosis, PHENOMENA AND PROCESSES::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproduction::Pregnancy, ENFERMEDADES::enfermedades del sistema inmune::enfermedades autoinmunes::síndrome antifosfolípido, COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas sanguíneas::inmunoproteínas::inmunoglobulinas::anticuerpos::autoanticuerpos::anticuerpos antifosfolípidos, ENFERMEDADES::enfermedades cardiovasculares::enfermedades vasculares::embolia y trombosis::trombosis, FENÓMENOS Y PROCESOS::fenómenos fisiológicos reproductivos y urinarios::fenómenos fisiológicos de la reproducción::reproducción::embarazo
الوصف:	Antiphospholipid antibodies; Obstetric antiphospholipid syndrome; Thrombotic antiphospholipid syndrome ; Anticuerpos antifosfolípidos; Síndrome antifosfolípido obstétrico; Síndrome antifosfolípido trombótico ; Anticossos antifosfolípids; Síndrome antifosfolípid obstètric; Síndrome antifosfolípid trombòtic ; Antiphospholipid syndrome (APS) is a systemic autoimmune condition characterised by the presence of antiphospholipid antibodies (aPL) associated with vascular thrombosis and/or pregnancy complications. In a cohort of 74 yet diagnosed APS individuals fulfilling Sydney laboratory criteria (twice positive for lupus anticoagulant, anticardiolipin, aCL, and/or anti-β2glycoprotein I, aβ2GPI), 33 out of 74 were obstetric APS (OAPS) and 41 thrombotic APS (TAPS) patients. 39% of TAPS patients were women. Although aPL detection was persistent, we observed an oscillatory aPL positivity in 56.7% and a transient seroconversion in 32.4% of APS patients at enrolment. Thus, we tested their sera in a line immunoassay that simultaneously detected IgG or IgM for criteria (aCL and aβ2GPI) and non-criteria (anti-phosphatidylserine, aPS; anti-phosphatidic acid, aPA; anti-phosphatidylinositol, aPI; anti-annexin 5, aA5; anti-prothrombin, aPT; anti-phosphatidylethanolamine; anti-phosphatidylglycerol, and anti-phosphatidylcholine) aPL. OAPS and TAPS patients displayed different but overlapping clusters based on their aPL reactivities. Specifically, while OAPS patients showed higher aPA, aPS, aA5, aβ2GPI and aPT IgM levels than TAPS patients, the latter displayed higher reactivity in aCL, aPI and aA5 IgG. Eventually, with a cut-off of the 99th percentile established from a population of 79 healthy donors, TAPS patients significantly tested more positive for aCL and aA5 IgG than OAPS patients, who tested more positive for aPA, aPS and aβ2GPI IgM. Transiently seronegative APS patients showed non-criteria aPL positivity twice in sera obtained 3 months apart. Overall, our data show that APS patients presented clusters of aPL that define ...
نوع الوثيقة:	article in journal/newspaper
وصف الملف:	application/pdf
اللغة:	English
تدمد:	1422-0067
Relation:	International Journal of Molecular Sciences;23(21); https://doi.org/10.3390/ijms232112819; Anunciación-Llunell A, Muñoz C, Roggenbuck D, Frasca S, Pardos-Gea J, Esteve-Valverde E, et al. Differences in Antiphospholipid Antibody Profile between Patients with Obstetric and Thrombotic Antiphospholipid Syndrome. Int J Mol Sci. 2022 Oct 24;23(21):12819.; https://hdl.handle.net/11351/8564; 000881159500001
DOI:	10.3390/ijms232112819
الاتاحة:	https://hdl.handle.net/11351/8564 https://doi.org/10.3390/ijms232112819
Rights:	Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/openAccess
رقم الانضمام:	edsbas.FD4432F7
قاعدة البيانات:	BASE

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تدمد:	14220067
DOI:	10.3390/ijms232112819