Academic Journal
Dystrophin Dp71 in PC12 cell adhesion.
| العنوان: | Dystrophin Dp71 in PC12 cell adhesion. |
|---|---|
| المؤلفون: | Enríquez-Aragón, Jose Arturo, Cerna-Cortés, Joel, Bermúdez de León, Mario, García-Sierra, Francisco, González, Everardo, Mornet, Dominique, Cisneros, Bulmaro |
| المساهمون: | Department of Genetics and Molecular Biology, Centro de Investigation y de Estudios Avanzados del IPN, Department of Cell Biology, Centro de Investigacion y de Estudios Avanzados del IPN, Muscle et pathologies, Université Montpellier 1 (UM1)-IFR3, Université Montpellier 1 (UM1)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| المصدر: | ISSN: 0959-4965 ; NeuroReport ; https://www.hal.inserm.fr/inserm-00149909 ; NeuroReport, 2005, 16 (3), pp.235-8. |
| بيانات النشر: | HAL CCSD Lippincott, Williams & Wilkins |
| سنة النشر: | 2005 |
| المجموعة: | Université de Montpellier: HAL |
| مصطلحات موضوعية: | MESH: Animals, MESH: Cell Adhesion, MESH: Neurites, MESH: Oligodeoxyribonucleotides, Antisense, MESH: PC12 Cells, MESH: Rats, MESH: Statistics, MESH: Cell Differentiation, MESH: Collagen, MESH: Dystrophin, MESH: Fibronectins, MESH: Fluorescent Antibody Technique, MESH: Integrin beta Chains, MESH: Laminin, MESH: Microscopy, Electron, Scanning, [SDV.BC]Life Sciences [q-bio]/Cellular Biology |
| الوصف: | Previously, we reported that PC12 cells with decreased Dp71 expression (antisense-Dp71 cells) display deficient nerve-growth-factor-induced neurite outgrowth. In this study, we show that disturbed neurite outgrowth of antisense-Dp71 cells is accompanied by decreased adhesion activity on laminin, collagen and fibronectin. In wild-type cells, the immunostaining of Dp71 and beta1-integrin overlaps in the basal area contacting the substrate, but staining of both proteins decrease in the antisense-Dp71 cells. Morphology of antisense-Dp71 cells at the electron microscopic level is characterized by the lack of filopodia, cellular projections involved in adhesion. Our findings suggest that Dp71 is required for the efficient PC12 cell attachment to beta1-integrin-dependent substrata and that decreased adhesion activity of the antisense-Dp71 cells could determine their deficiency to extend neurites. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/15706226; inserm-00149909; https://www.hal.inserm.fr/inserm-00149909; https://www.hal.inserm.fr/inserm-00149909/document; https://www.hal.inserm.fr/inserm-00149909/file/Enriquez-Aragon_et_al_Neuroreport.pdf; PUBMED: 15706226 |
| الاتاحة: | https://www.hal.inserm.fr/inserm-00149909 https://www.hal.inserm.fr/inserm-00149909/document https://www.hal.inserm.fr/inserm-00149909/file/Enriquez-Aragon_et_al_Neuroreport.pdf |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.FD30D8A3 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |