Academic Journal
Tgf-β, Wnt, and Fgf Signaling Pathways During Axolotl Tail Regeneration and Forelimb Bud Development ...
| العنوان: | Tgf-β, Wnt, and Fgf Signaling Pathways During Axolotl Tail Regeneration and Forelimb Bud Development ... |
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| المؤلفون: | Qiu, Qingchao |
| بيانات النشر: | University of Kentucky Libraries |
| سنة النشر: | 2019 |
| المجموعة: | DataCite Metadata Store (German National Library of Science and Technology) |
| الوصف: | Tgf-β, Wnt, and Fgf signaling pathways are required for many developmental processes. Here, I investigated the requirement of these signaling pathways during tail regeneration and limb development in the Mexican axolotl (Ambystoma mexicanum). Using small chemical inhibitors during tail regeneration, I found that the Tgf-β signaling pathway was required from 0-24 and 48-72 hours post tail amputation (hpa), the Wnt signaling pathway was required from 0-120 hpa, and the Fgf signaling pathway was required from 0-12hpa. Tgf-β1 was upregulated after amputation and thus may mediate Tgf-β signaling pathway during tail regeneration. Both Smad-mediated and non-Smad mediated Tgf-β signaling were activated as early as 1hpa. Smad-mediated Tgf-β signaling via activated pSmad2 and pSmad3, and via phosphorylated Erk and Akt. Two different Tgf-β signaling pathway inhibitors, SB505124 and Naringenin, differentially regulated pSmad2, pSmad3, p-Erk, and p-Akt, while SB505124 and Naringenin both inhibited tail regeneration; only ... : Copyright © Qingchao Qiu 2019 ... |
| نوع الوثيقة: | text doctoral or postdoctoral thesis thesis |
| اللغة: | unknown |
| DOI: | 10.13023/etd.2019.367 |
| الاتاحة: | https://dx.doi.org/10.13023/etd.2019.367 https://uknowledge.uky.edu/neurobio_etds/24/ |
| رقم الانضمام: | edsbas.FCC0384B |
| قاعدة البيانات: | BASE |
| DOI: | 10.13023/etd.2019.367 |
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