Academic Journal
A nitric oxide synthesis inhibitor in the medial preoptic area inhibits copulation and stimulus sensitization in male rats
| العنوان: | A nitric oxide synthesis inhibitor in the medial preoptic area inhibits copulation and stimulus sensitization in male rats |
|---|---|
| المؤلفون: | Gwen Lagoda, John W. Muschamp, Anna Vigdorchik, Elaine M. Hull |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://www.elaine-m-hull.com/publications/NO_synthesis_inhibitor.pdf. |
| سنة النشر: | 2004 |
| المجموعة: | CiteSeerX |
| الوصف: | Dopamine in the medial preoptic area (MPOA) facilitates copulation in male rats, and nitric oxide (NO) regulates basal and female-stimulated MPOA dopamine release. Microinjection of L-nitro-arginine methyl ester (L-NAME, an NO synthesis inhibitor) into the MPOA blocked copulation in naive rats and impaired copulation in sexually experienced males. In other naive rats, L-NAME or saline was microinjected into the MPOA before each of 7 daily exposures to a receptive female placed over their cage. In a drug-free test on Day 8, copulation by L-NAME-treated rats was similar to that of unexposed controls and was impaired relative to saline-treated males. Therefore, NO in the MPOA is important for copulation and stimulus sensitization in male rats. Nitric oxide (NO) may facilitate male sexual behavior in several ways. NO acts peripherally as a vasodilator, causing relaxation of the corpus cavernosum and thereby leading to erection (Ignarro et al., 1990; Kim, Azadzoi, Goldstein, & Saenz de Tejada, 1991). Systemic injections of the NO synthase (NOS) inhibitor L-nitroarginine methyl ester (L-NAME) impaired copulation in sexually experienced male rats by reducing the numbers of intromissions |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.321.8778; http://www.elaine-m-hull.com/publications/NO_synthesis_inhibitor.pdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.321.8778 http://www.elaine-m-hull.com/publications/NO_synthesis_inhibitor.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.FC690D16 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |