التفاصيل البيبلوغرافية
| العنوان: |
Exploration of the main active components and pharmacological mechanism of Yerba Mate based on network pharmacology |
| المؤلفون: |
Yue, Zhaodi, Fu, Hui, Ma, Huifen, Li, Li, Feng, Ziyun, Yin, Yanyan, Wang, Fangqi, Du, Bingyu, Liu, Yibo, Zhao, Renjie, Kan, Mengfan, Sun, Helin, Zhang, Zhongwen, Yu, Shaohong |
| المصدر: |
Endokrynologia Polska; Vol 73, No 4 (2022); 725-735 |
| بيانات النشر: |
Via Medica |
| سنة النشر: |
2022 |
| المجموعة: |
Via Medica Journals |
| مصطلحات موضوعية: |
yerba mate, pharmacological mechanism, biotargets, network pharmacology |
| الوصف: |
Introduction: Yerba mate is widely consumed in South American countries and is gaining popularity around the world. Long-term consumption of yerba mate has been proven to have health-care functions and therapeutic effects on many diseases; however, its underlying mechanism has not been clearly elucidated. In this research, we explored the pharmacological mechanism of yerba mate through a network pharmacological approach. Material and methods: The bioactive components of yerba mate were screened from published literature and the Traditional Chinese Medicine System Pharmacology Database (TCMSP), and the targets and related diseases were retrieved by TCMSP. Furthermore, the component-target-disease network an protein-protein interaction (PPI) network were constructed, and combined with gene ontology (GO) functional analysis and Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway enrichment analysis to explore the pharmacological mechanism of yerba mate. Results: As a result, 16 bioactive components of yerba mate were identified, which acted on 229 targets in total. Yerba mate can be used to treat 305 diseases, such as breast cancer, asthma, Alzheimer’s disease, osteoarthritis, diabetes mellitus, atherosclerosis, and obesity. Protein kinase B (AKT1), signal transducer and activator of transcription 3 (STAT3), mitogen-activated protein kinase 1 (MAPK1), transcription factor AP-1 (JUN), cellular tumour antigen (p53) TP53, tumour necrosis factor (TNF), transcription factor p65 (RELA), interleukin-6 (IL6), amyloid-beta precursor protein (APP), and vascular endothelial growth factor A (VEGFA) were identified as the key targets of yerba mate playing pharmacological roles. The signalling pathways identified by KEGG pathway enrichment analysis that were most closely related to the effects of yerba mate included pathways in cancer, fluid shear stress and atherosclerosis, and human cytomegalovirus infection. Conclusion: the results of our study preliminarily verify the basic pharmacological action and possible mechanism ... |
| نوع الوثيقة: |
other/unknown material |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
https://journals.viamedica.pl/endokrynologia_polska/article/downloadSuppFile/87812/343630; https://journals.viamedica.pl/endokrynologia_polska/article/view/EP.a2022.0026 |
| DOI: |
10.5603/EP.a2022.0026 |
| الاتاحة: |
https://journals.viamedica.pl/endokrynologia_polska/article/view/EP.a2022.0026
https://doi.org/10.5603/EP.a2022.0026 |
| Rights: |
Completion of the online submission form electronically is tantamount to automatically and free-of-charge transferring of the copyright for publishing and distribution of the submitted material (in all known now and developed in the future forms and fields of exploitation) to the copyright holder, i.e. Polish Society of Endocrinology, under condition that those materials are accepted for publication. The authors agree not to publish any data or figures presented in their work anywhere and in any language without the prior written consent. ; Przesyłając manuskrypt wraz z ilustracjami i tabelami, Autorzy automatycznie i nieodpłatnie przenoszą na Polskie Towarzystwo Endokrynologiczne i "Endokrynologię Polską" wszelkie prawa autorskie do wydawania oraz rozpowszechniania nadesłanych materiałów we wszystkich znanych formach i na wszystkich znanych polach eksploatacji, bez ograniczeń terytorialnych językowych, pod warunkiem że materiały te zostaną zaakceptowane do publikacji. Publikacja w całości ani w żadna jej część nie może być powielana ani upowszechniana w jakikolwiek mechaniczny lub elektroniczny sposób bez pisemnej zgody Redaktora Naczelnego. |
| رقم الانضمام: |
edsbas.FC26BC97 |
| قاعدة البيانات: |
BASE |