Academic Journal
A ganglioside-based immune checkpoint enables senescent cells to evade immunosurveillance during aging
| العنوان: | A ganglioside-based immune checkpoint enables senescent cells to evade immunosurveillance during aging |
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| المؤلفون: | Iltis, Charlène, Moskalevska, Iryna, Debiesse, Antoine, Seguin, Laetitia, Fissoun, Christina, Cervera, Ludovic, Moudombi, Lyvia, Ardin, Maude, Ferrari, Anthony, Eliott, Coline, Pisani, Didier, Ottaviani, Alexandre, Bourinet, Manon, Luci, Carmelo, Gual, Philippe, Makulyte, Gabriela, Bernard, David, Durandy, Manon, Duret, Lou, Hamidouche, Tynhinane, Kunz, Sarah, Croce, Olivier, Delannoy, Clément, Gueŕardel, Yann, Allain, Fabrice, Hofman, Paul, Benarroch-Popivker, Delphine, Bianchini, Laurence, Dadone-Montaudie, Berengere, Cosson, Estelle, Guglielmi, Julien, Pourcher, Thierry, Braud, Véronique, Shkreli, Marina, Pers, Yves-Marie, Jorgensen, Christian, Brondello, Jean-Marc, Feral, Chloé, Michallet, Marie-Cécile, Gilson, Eric, Cherfils-Vicini, Julien |
| المساهمون: | Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard Lyon -Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Synergie Lyon Cancer-Platform of Bioinformatics-Gilles Thomas, Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre Léon Bérard Lyon -Université Claude Bernard Lyon 1 (UCBL), Laboratoire de PhysioMédecine Moléculaire (LP2M), Université Nice Sophia Antipolis (1965 - 2019) (UNS)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UniCA), Institut de pharmacologie moléculaire et cellulaire (IPMC), Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Cellules souches mésenchymateuses, environnement articulaire et immunothérapies de la polyarthrite rhumatoide, Université Montpellier 1 (UM1)-IFR3, Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de paléontologie et paleogéographie du paleozoique (LPPP), Université de Lille, Sciences et Technologies-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | ISSN: 2662-8465. |
| بيانات النشر: | CCSD Nature |
| سنة النشر: | 2024 |
| المجموعة: | Institut national des sciences de l'Univers: HAL-INSU |
| مصطلحات موضوعية: | [SDV.CAN]Life Sciences [q-bio]/Cancer |
| الوصف: | International audience ; Although senescent cells can be eliminated by the immune system, they tend to accumulate with age in various tissues. Here we show that senescent cells can evade immune clearance by natural killer (NK) cells by upregulating the expression of the disialylated ganglioside GD3 at their surface. The increased level of GD3 expression on senescent cells that naturally occurs upon aging in liver, lung, kidney or bones leads to a strong suppression of NK-cell-mediated immunosurveillance. In mice, we found that targeting GD3+ senescent cells with anti-GD3 immunotherapy attenuated the development of experimentally induced or age-related lung and liver fibrosis and age-related bone remodeling. These results demonstrate that GD3 upregulation confers immune privilege to senescent cells. We propose that GD3 acts as a senescence immune checkpoint (SIC) that allows senescent cells to escape immunosurveillance and to trigger immune anergy during aging |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | BIORXIV: 2021.04.23.440408 |
| DOI: | 10.1101/2021.04.23.440408 |
| الاتاحة: | https://cnrs.hal.science/hal-04802818 https://cnrs.hal.science/hal-04802818v1/document https://cnrs.hal.science/hal-04802818v1/file/Iltis%20et%20al%20editing%20v5.pdf https://doi.org/10.1101/2021.04.23.440408 |
| رقم الانضمام: | edsbas.FBEB90FD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1101/2021.04.23.440408 |
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