Book
Therapeutic immunization strategies against cervical cancer:induction of cell-mediated immunity in murine models
| العنوان: | Therapeutic immunization strategies against cervical cancer:induction of cell-mediated immunity in murine models |
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| المؤلفون: | Bungener, Laura Barbara |
| المصدر: | Bungener , L B 2004 , ' Therapeutic immunization strategies against cervical cancer : induction of cell-mediated immunity in murine models ' , Doctor of Philosophy . |
| سنة النشر: | 2004 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | 44.92 gynaecologie en obstetrie, Proefschriften (vorm), Baarmoederhalskanker, Immuunreacties, Therapieën |
| الوصف: | The aim of the study described in this thesis is the development of a therapeutic immunization strategy against cervical cancer and pre-malignant precursor lesions of cervical cancer (CIN lesions). Cervical cancer is caused by high risk human papillomavirus (HPV). Two of the early proteins of high risk HPV, E6 and E7, interact with the cell cycle regulation proteins p53 and pRb and can cause immortalization of cells. E6 and E7 are constitutively expressed by cervical cancer cells, making these proteins attractive targets for an immunotherapy directed against HPV-induced cervical cancer. In this thesis two strategies for effective induction of immune responses against protein antigens are explored: immunization with recombinant Semliki Forest virus (rSFV) and influenza virosomes containing protein antigens. Furthermore, the underlying mechanisms of cytotoxic T lymphocyte (CTL) induction by these immunizations are investigated. |
| نوع الوثيقة: | book |
| وصف الملف: | application/pdf |
| اللغة: | English |
| ردمك: | 978-90-6464-304-0 90-6464-304-0 |
| Relation: | https://research.rug.nl/en/publications/7e7b4080-7477-480f-a5ef-a30faf74bf90; urn:ISBN:9064643040 |
| الاتاحة: | https://hdl.handle.net/11370/7e7b4080-7477-480f-a5ef-a30faf74bf90 https://research.rug.nl/en/publications/7e7b4080-7477-480f-a5ef-a30faf74bf90 https://pure.rug.nl/ws/files/2969047/titlecon.pdf https://pure.rug.nl/ws/files/2969048/c1.pdf https://pure.rug.nl/ws/files/2969049/c2.pdf https://pure.rug.nl/ws/files/2969050/c3.pdf https://pure.rug.nl/ws/files/2969051/c4.pdf https://pure.rug.nl/ws/files/2969052/c5.pdf https://pure.rug.nl/ws/files/2969053/c6.pdf https://pure.rug.nl/ws/files/2969054/c7.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.FBB1D454 |
| قاعدة البيانات: | BASE |
| ردمك: | 9789064643040 9064643040 |
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