Report
Visual activity enhances neuronal excitability in thalamic relay neurons
| العنوان: | Visual activity enhances neuronal excitability in thalamic relay neurons |
|---|---|
| المؤلفون: | Duménieu, Maël, Fronzaroli-Molinieres, Laure, Iborra-Bonnaure, Cécile, Wakade, Anushka, Zanin, Emilie, Aziz, Aurore, Ankri, Norbert, Incontro, Salvatore, Denis, Danièle, Brette, Romain, Marquèze-Pouey, Béatrice, Debanne, Dominique, Russier, Michael |
| المساهمون: | Unité de Neurobiologie des canaux Ioniques et de la Synapse (UNIS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Marseille, Institut de la Vision, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), ANR-17-CE16-0022,LoGIK,Modulation de l'excitabilité neuronale par LGI1(2017), ANR-21-CE16-0013,PLASTINEX,Plasticité de l'excitabilité intrinsèque dans les neurones du thalamus visuel(2021) |
| المصدر: | https://amu.hal.science/hal-04286194 ; 2023. |
| بيانات النشر: | HAL CCSD |
| سنة النشر: | 2023 |
| المجموعة: | Aix-Marseille Université: HAL |
| مصطلحات موضوعية: | dorsal LGN, Kv1 channel, intrinsic plasticity, activity-dependent plasticity, vision, amblyopia, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] |
| الوصف: | The dorsal lateral geniculate nucleus (dLGN) has long been held to act as a basic relay forvisual information travelling from the retina to cortical areas, but recent findings suggest alargely underestimated functional plasticity of dLGN neurons. However, the cellularmechanisms supporting this functional plasticity have not been yet explored. In particular, itremains to elucidate whether intrinsic neuronal excitability change upon visual stimuli. Weshow here that monocular deprivation for 10 days reduces the intrinsic excitability of dorsalLGN relay cells. Furthermore, dLGN neurons exhibit long-term potentiation of their intrinsicexcitability (LTP-IE) when suprathreshold afferent retinal inputs are stimulated at 40 Hz orwhen spikes are induced with direct somatic current injection to reproduce patterns of retinalactivity. LTP-IE is observed after eye opening and requires calcium influx mediated by L-typecalcium channels. It involves activation of PKA and is expressed through the down-regulationof Kv1 potassium channels. In conclusion, our study provides the first evidence for intrinsicplasticity in dLGN relay cells, thus further pointing the role of thalamic neurons in activity-dependent visual plasticity and amblyopia. |
| نوع الوثيقة: | report |
| اللغة: | English |
| Relation: | hal-04286194; https://amu.hal.science/hal-04286194; https://amu.hal.science/hal-04286194/document; https://amu.hal.science/hal-04286194/file/BIORXIV-2023-543854v1-Debanne.pdf |
| الاتاحة: | https://amu.hal.science/hal-04286194 https://amu.hal.science/hal-04286194/document https://amu.hal.science/hal-04286194/file/BIORXIV-2023-543854v1-Debanne.pdf |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.FBB048D0 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |