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Systematic investigation of organochlorine pesticides and polychlorinated biphenyls blood levels in Greek children from the Rhea birth cohort suggests historical exposure to DDT and through diet to DDE

التفاصيل البيبلوغرافية
العنوان: Systematic investigation of organochlorine pesticides and polychlorinated biphenyls blood levels in Greek children from the Rhea birth cohort suggests historical exposure to DDT and through diet to DDE
المؤلفون: Costopoulou, D, Kedikoglou, K, Vafeiadi, M, Roumeliotaki, T, Margetaki, K, Stephanou, E, Myridakis, A, Leondiadis, L
بيانات النشر: Elsevier
سنة النشر: 2024
المجموعة: Brunel University London: Brunel University Research Archive (BURA)
مصطلحات موضوعية: environmental exposures, DDT, DDE, PCBs, early life, children
الوصف: Data availability: Data will be made available on request. ; Supplementary data are available online at: https://www.sciencedirect.com/science/article/pii/S0160412024002721#s0090:~:text=Appendix%20A.-,Supplementary%20data,-Data%20availability . ; The blood levels of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) have been thoroughly investigated in Greek children from the Rhea birth cohort study. This investigation aimed to assess exposure levels, explore their possible relationship with children's age and sex, and indicate potential sources of exposure. Exposure patterns and common sources of PCBs and OCPs were analyzed using bivariate and multivariate statistics. A total of 947 blood samples from study participants were analyzed for OCP and PCB exposure, with 375 samples collected at 4 years old, 239 at 6.5 years old, and 333 at 11 years old. Elevated levels of DDE were observed in 6.5-year-old children compared to corresponding levels in other European countries. Higher levels of DDE were found in 4-year-old children, with the lowest concentrations in the 11-year-old group. The DDT/DDE ratio was consistently less than 1 among all the examined subjects. These results indicate exposure to DDT and DDE both in utero and through breastfeeding and dietary intake. For the entire cohort population, the highest concentration was determined for PCB 28, followed by PCBs 138, 153, and 180. The sum of the six indicator PCBs implied low exposure levels for the majority of the cohort population. Spearman correlations revealed strong associations between PCBs and OCPs, while principal component analysis identified two different groupings of exposure. DDE exhibited a correlation with a series of PCBs (153, 156, 163, 180), indicating a combined OCP-PCB source, and an anticorrelation with others (52, 28, 101), implying a separate and competing source. ; Hellenic Ministry of Health and the General Secretariat for Research and Innovation.
نوع الوثيقة: article in journal/newspaper
وصف الملف: 1 - 12; Print-Electronic
اللغة: English
تدمد: 0160-4120
1873-6750
Relation: Environment International; ORCiD: Theano Roumeliotaki orcid:0000-0002-5044-983X; ORCiD: Euripides G. Stephanou orcid:0000-0002-0841-2953; ORCiD: Antonis Myridakis orcid:0000-0003-1690-6651; 108686; Costopoulou, D. et al. (2024) 'Systematic investigation of organochlorine pesticides and polychlorinated biphenyls blood levels in Greek children from the Rhea birth cohort suggests historical exposure to DDT and through diet to DDE', Environment International, 187, 108686, pp. 1 - 12. doi:10.1016/j.envint.2024.108686.; https://bura.brunel.ac.uk/handle/2438/28984; https://doi.org/10.1016/j.envint.2024.108686
DOI: 10.1016/j.envint.2024.108686
الاتاحة: https://bura.brunel.ac.uk/handle/2438/28984
https://doi.org/10.1016/j.envint.2024.108686
Rights: Copyright © 2024 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (https://creativecommons.org/licenses/by/4.0/). ; https://creativecommons.org/licenses/by/4.0/ ; https://creativecommons.org/licenses/by/4.0/legalcode.en ; The Authors
رقم الانضمام: edsbas.FB8C026A
قاعدة البيانات: BASE
الوصف
تدمد:01604120
18736750
DOI:10.1016/j.envint.2024.108686