التفاصيل البيبلوغرافية
| العنوان: |
Juvenile Spermatogonial Depletion (jsd) Mutant Seminiferous Tubules Are Capable of Supporting Transplanted Spermatogenesis1 |
| المؤلفون: |
H. L. Boettger-Tong, D. S. Johnston, L. D. Russell, M. D. Griswold, C. E. Bishop |
| المساهمون: |
H. L. Boettger-Tong, D. S. Johnston, L. D. Russell, M. D. Griswold, C. E. Bishop |
| المصدر: |
https://doi.org/10.1095/biolreprod63.4.1185. |
| بيانات النشر: |
Society for the Study of Reproduction |
| سنة النشر: |
2000 |
| المجموعة: |
BioOne Online Journals |
| جغرافية الموضوع: |
world |
| الوصف: |
In mice, the juvenile spermatogonial depletion (jsd) mutation results in a single wave of spermatogenesis followed by failure of type A spermatogonial stem cells to repopulate the testis, rendering male animals sterile. It is not clear whether the defect in jsd resides in a failure of the somatic component to support spermatogenesis or in a failure that is intrinsic to the mutant's germ cells. To determine if the jsd intratesticular environment is capable of supporting spermatogenesis, germ cell transplantation experiments were performed in which C57BL/6 ROSA germ cells were transplanted into jsd recipients. To determine if jsd spermatogonia are able to develop in a permissive seminiferous environment, jsd germ cells were transplanted into W/Wv and busulfan-treated C57BL/6 animals. The data demonstrate that up to 7 mo after transplantation of normal germ cells, jsd seminiferous tubules are capable of supporting spermatogenesis. In contrast, when jsd germ cells were transplanted into busulfan-treated C57BL/6 testis, or into testis of W/Wv mice, no jsd-derived spermatogenesis was observed. The data support the hypothesis that the jsd phenotype is due to a defect in the germ cells themselves, and not in the intratubular environment. |
| نوع الوثيقة: |
text |
| وصف الملف: |
text/HTML |
| اللغة: |
English |
| DOI: |
10.1095/biolreprod63.4.1185 |
| الاتاحة: |
https://doi.org/10.1095/biolreprod63.4.1185 |
| Rights: |
All rights reserved. |
| رقم الانضمام: |
edsbas.FB85665C |
| قاعدة البيانات: |
BASE |