التفاصيل البيبلوغرافية
| العنوان: |
The Role of Cardiac Resynchronization Therapy for the Management of Functional Mitral Regurgitation |
| المؤلفون: |
Eleonora Russo, Giulio Russo, Mauro Cassese, Maurizio Braccio, Massimo Carella, Paolo Compagnucci, Antonio Dello Russo, Michela Casella |
| المصدر: |
Cells; Volume 11; Issue 15; Pages: 2407 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2022 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
cardiac resynchronization therapy, functional mitral regurgitation, dyssynchrony, heart failure, LV remodeling |
| الوصف: |
Valve leaflets and chordae structurally normal characterize functional mitral regurgitation (FMR), which in heart failure (HF) setting results from an imbalance between closing and tethering forces secondary to alterations in the left ventricle (LV) and left atrium geometry. In this context, FMR impacts the quality of life and increases mortality. Despite multiple medical and surgical attempts to treat FMR, to date, there is no univocal treatment for many patients. The pathophysiology of FMR is highly complex and involves several underlying mechanisms. Left ventricle dyssynchrony may contribute to FMR onset and worsening and represents an important target for FMR management. In this article, we discuss the mechanisms of FMR and review the potential therapeutic role of CRT, providing a comprehensive review of the available data coming from clinical studies and trials. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Cells of the Cardiovascular System; https://dx.doi.org/10.3390/cells11152407 |
| DOI: |
10.3390/cells11152407 |
| الاتاحة: |
https://doi.org/10.3390/cells11152407 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.FB74B37B |
| قاعدة البيانات: |
BASE |