Academic Journal
Assessment of a rapid diagnostic test to exclude bacteraemia and effect on clinical decision-making for antimicrobial therapy
العنوان: | Assessment of a rapid diagnostic test to exclude bacteraemia and effect on clinical decision-making for antimicrobial therapy |
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المؤلفون: | Yui, Samuel, Bercades, Georgia, Muzslay, Monika, Blackburn, Emma, Ali, Shanom, Smyth, Deborah, Macklin, Alison, Ryu, Jung Hyun, Bassett, Paul, MacCallum, Niall, Brealey, David, Wilson, Peter |
المساهمون: | DH | National Institute for Health Research, This work was supported by an unrestricted grant from Momentum Bioscience Ltd and the National Institute for Health Research University College London Hospitals Biomedical Research Centre. |
المصدر: | Scientific Reports ; volume 10, issue 1 ; ISSN 2045-2322 |
بيانات النشر: | Springer Science and Business Media LLC |
سنة النشر: | 2020 |
الوصف: | Unnecessary antimicrobial treatment promotes the emergence of resistance. Early confirmation that a blood culture is negative could shorten antibiotic courses. The Cognitor Minus test, performed on blood culture samples after 12 hours incubation has a negative predictive value (NPV) of 99.5%. The aim of this study was to determine if earlier confirmation of negative blood culture result would shorten antibiotic treatment. Paired blood cultures were taken in the Critical Care Unit at a teaching hospital. The Cognitor Minus test was performed on one set >12 hours incubation but results kept blind. Clinicians were asked after 24 and 48 hours whether a result excluding bacteraemia or fungaemia would affect decisions to continue or stop antimicrobial treatment. Over 6 months, 125 patients were enrolled. The median time from start of incubation to Cognitor Minus test was 27.1 hours. When compared to 5 day blood culture results from both the control and test samples, Cognitor Minus gave NPVs of 99% and 100% respectively. Test results would have reduced antibiotic treatment in 14% (17/119) of patients at 24 and 48 hours (24% at either time) compared with routine blood culture. The availability of rapid tests to exclude bacteraemia may be of benefit in antimicrobial stewardship. |
نوع الوثيقة: | article in journal/newspaper |
اللغة: | English |
DOI: | 10.1038/s41598-020-60072-9 |
الاتاحة: | http://dx.doi.org/10.1038/s41598-020-60072-9 https://www.nature.com/articles/s41598-020-60072-9.pdf https://www.nature.com/articles/s41598-020-60072-9 |
Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
رقم الانضمام: | edsbas.FB418576 |
قاعدة البيانات: | BASE |
DOI: | 10.1038/s41598-020-60072-9 |
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