التفاصيل البيبلوغرافية
| العنوان: |
Additional file 4 of Replication catastrophe is responsible for intrinsic PAR glycohydrolase inhibitor-sensitivity in patient-derived ovarian cancer models |
| المؤلفون: |
Camilla Coulson-Gilmer (11572995), Robert D. Morgan (10517033), Louisa Nelson (9620785), Bethany M. Barnes (11375268), Anthony Tighe (34618), René Wardenaar (3595967), Diana C. J. Spierings (11510967), Helene Schlecht (11572998), George J. Burghel (11375271), Floris Foijer (3421868), Sudha Desai (589177), Joanne C. McGrail (11375274), Stephen S. Taylor (7184861) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biophysics, Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Cancer, Hematology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, High-grade serous ovarian cancer, PARG inhibitor, DNA replication, Replication stress, Gene expression signature, Predictive biomarkers |
| الوصف: |
Additional file 4: Fig. S4. Comparison of NanoString with CCLE and Klijn datasets; DNA replication and mitotic gene expression correlation. (A) Box and whisker plots for DNA replication (red), mitotic (blue) and apoptotic (grey) gene Z scores in 10 cell line panel. Values on left side indicate Pearson R2 for CCLE or data from Klijn et al., compared with the NanoString analysis. (B) XY plot of the correlation between DNA replication and mitotic (red), and DNA replication and apoptotic (grey) gene expression. Z scores sums for epithelial cancer cell lines in Broad 2019 CCLE dataset [39]. Ten cell line panel indicated by black diamonds, note OV56 CCLE expression data does not reflect NanoString expression data (see text). Pearson R2 values indicated below the graph, all comparisons, p < 0.0001, total number cell lines 747. ns = not significant, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/Additional_file_4_of_Replication_catastrophe_is_responsible_for_intrinsic_PAR_glycohydrolase_inhibitor-sensitivity_in_patient-derived_ovarian_cancer_models/16822755 |
| DOI: |
10.6084/m9.figshare.16822755.v1 |
| الاتاحة: |
https://doi.org/10.6084/m9.figshare.16822755.v1 |
| Rights: |
CC BY + CC0 |
| رقم الانضمام: |
edsbas.FB08B8B5 |
| قاعدة البيانات: |
BASE |