Academic Journal
Early intravenous beta-blockers in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction:A patient-pooled meta-analysis of randomized clinical trials
| العنوان: | Early intravenous beta-blockers in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction:A patient-pooled meta-analysis of randomized clinical trials |
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| المؤلفون: | Hoedemaker, Niels P. G., Roolvink, Vincent, de Winter, Robbert J., van Royen, Niels, Fuster, Valentin, Garcia-Ruiz, Jose M., Er, Fikret, Gassanov, Natig, Hanada, Kenji, Okumura, Ken, Ibanez, Borja, van 't Hof, Arnoud W., Damman, Peter |
| المصدر: | Hoedemaker , N P G , Roolvink , V , de Winter , R J , van Royen , N , Fuster , V , Garcia-Ruiz , J M , Er , F , Gassanov , N , Hanada , K , Okumura , K , Ibanez , B , van 't Hof , A W & Damman , P 2020 , ' Early intravenous beta-blockers in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction : A patient-pooled meta-analysis of randomized clinical trials ' , European Heart Journal: Acute Cardiovascular Care , vol. 9 , no. .... |
| سنة النشر: | 2020 |
| المجموعة: | Maastricht University Research Publications |
| مصطلحات موضوعية: | ST-segment elevation myocardial infarction, primary percutaneous coronary intervention, intravenous beta-blockers, beta-blockers, outcomes, EARLY METOPROLOL, SIZE |
| الوصف: | Background: Conflicting evidence is available on the efficacy and safety of early intravenous beta-blockers before primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. We performed a patient-pooled meta-analysis of trials comparing early intravenous beta-blockers with placebo or routine care in ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention. Aim: The aim of this study was to evaluate the clinical and safety outcomes of intravenous beta-blockers in ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention. Methods: Four randomized trials with a total of 1150 patients were included. The main outcome was one-year death or myocardial infarction. Secondary outcomes included biomarker-based infarct size, left ventricular ejection fraction during follow-up, ventricular tachycardia, and a composite safety outcome (cardiogenic shock, symptomatic bradycardia, or hypotension) during hospitalization. Results: One-year death or myocardial infarction was similar among beta-blocker (4.2%) and control patients (4.4%) (hazard ratio: 0.96 (95% confidence interval: 0.53-1.75, p=0.90, I-2=0%). No difference was observed in biomarker-based infarct size. One-month left ventricular ejection fraction was similar, but left ventricular ejection fraction at six months was significantly higher in patients treated with early intravenous beta-blockade (52.8% versus 50.0% in the control group, p=0.03). No difference was observed in the composite safety outcome or ventricular tachycardia during hospitalization. Conclusion: In ST-segment elevation myocardial infarction patients undergoing primary percutaneous coronary intervention, the administration of early intravenous beta-blockers was safe. However, there was no difference in the main outcome of one-year death or myocardial infarction with early intravenous beta-blockers. A larger clinical trial is warranted to confirm the definitive efficacy of ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/2048872619830609 |
| الاتاحة: | https://cris.maastrichtuniversity.nl/en/publications/800516ff-bcb7-4c71-a034-54eda80535e2 https://doi.org/10.1177/2048872619830609 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.FAD3216C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/2048872619830609 |
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