Academic Journal
Point and interval estimation following a sequential clinical trial
| العنوان: | Point and interval estimation following a sequential clinical trial |
|---|---|
| المؤلفون: | Susan Todd, John Whitehead, Karen M. Facey |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://biomet.oxfordjournals.org/cgi/reprint/83/2/453.pdf. |
| سنة النشر: | 1996 |
| المجموعة: | CiteSeerX |
| مصطلحات موضوعية: | Some key words, Bias adjustment, Clinical trial, Confidence interval, Estimation, Sequential analysis |
| الوصف: | The usual methodology employed in analysis after a sequential clinical trial is based on orderings of the possible samples resulting from the design. However, this approach lacks flexibility for use in wider applications. In this paper two estimation techniques not based on orderings are considered and modified to obtain improved accuracy. A bias-adjusted maximum likelihood estimate together with a new and general method for setting confidence limits are discussed. The realistic scenario of group sequential monitoring is assumed and methods for exact estimation are given. Accuracy of the methodology after a triangular test and an O'Brien & Fleming test are demonstrated through simulation. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.136.1867; http://biomet.oxfordjournals.org/cgi/reprint/83/2/453.pdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.136.1867 http://biomet.oxfordjournals.org/cgi/reprint/83/2/453.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.FACE1500 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |