Academic Journal
Amplified Targeted Drug Delivery Independent of Target Number through Alternative Administration of Two Matched Nanoparticles
| العنوان: | Amplified Targeted Drug Delivery Independent of Target Number through Alternative Administration of Two Matched Nanoparticles |
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| المؤلفون: | Mengwen Song, Ruiyuan Cao, Xingjuan Chen, Cui Wang, Xiaowen Xing, Wei Li, Yuexiang Li, Yajin Liao, Wu Zhong, Qihong Li, Zhiqiang Liu |
| سنة النشر: | 1753 |
| مصطلحات موضوعية: | Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Cancer, Space Science, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, selective drug delivery, enhancing drug loading, enhance drug delivery, disease site despite, breast cancer model, brain injury model, although several strategies, significantly enhanced chemotherapy, molecular targets provides, limited molecular targets, molecular targets, enhanced permeability, vivo <, vitro <, tumor cells, therapeutic outcome, target cells, study describes, specific binding |
| الوصف: | Targeting nanoparticles (NPs) based on the specific binding of ligands with molecular targets provides a promising tool for tissue-selective drug delivery. However, the number of molecular targets on the cell surface is limited, hindering the number of NPs that can bind and, thus, limiting the therapeutic outcome. Although several strategies have been developed to enhance drug delivery, such as enhancing drug loading and circulation time or increasing the enhanced permeability and retention effect of nanocarriers, none have resolved this issue. Herein, we designed a simple method for amplified and targeted drug delivery using two matched NPs. One NP was aptamer-functionalized to specifically bind to target cells, while the other was aptamer-complementary DNA-functionalized to specifically bind to aptamer-NPs. Alternate administration of the two matched NPs enables their continuous accumulation in the disease site despite their limited molecular targets. As a proof of concept, the method was tested in a breast cancer model and significantly enhanced chemotherapy of tumor cells in vitro and in vivo . The potential applications of this method in a brain injury model were also demonstrated. Overall, the study describes a method for amplified targeted drug delivery independent of the target number. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/journal_contribution/Amplified_Targeted_Drug_Delivery_Independent_of_Target_Number_through_Alternative_Administration_of_Two_Matched_Nanoparticles/24714569 |
| DOI: | 10.1021/acsnano.3c04059.s001 |
| الاتاحة: | https://doi.org/10.1021/acsnano.3c04059.s001 https://figshare.com/articles/journal_contribution/Amplified_Targeted_Drug_Delivery_Independent_of_Target_Number_through_Alternative_Administration_of_Two_Matched_Nanoparticles/24714569 |
| Rights: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.FAC0D662 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/acsnano.3c04059.s001 |
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