Academic Journal
AIDS incidence and survival in a hospital‐based cohort of HIV‐positive patients from São Paulo, Brazil: The role of IFN‐λ4 polymorphisms
| العنوان: | AIDS incidence and survival in a hospital‐based cohort of HIV‐positive patients from São Paulo, Brazil: The role of IFN‐λ4 polymorphisms |
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| المؤلفون: | da Silva Prates, Gabriela, Malta, Fernanda M., de Toledo Gonçalves, Fernanda, Monteiro, Mariana A., Fonseca, Luiz Augusto M., R. Veiga, Ana Paula, M. C. Magri, Marcello, Duarte, Alberto J. S., Casseb, Jorge, Assone, Tatiane |
| المساهمون: | Conselho Nacional de Desenvolvimento Científico e Tecnológico |
| المصدر: | Journal of Medical Virology ; volume 93, issue 6, page 3601-3606 ; ISSN 0146-6615 1096-9071 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2020 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Few studies have reported the prognosis of human immunodeficiency virus (HIV)‐positive patients followed for a long time in Brazil, particularly those including pre and post‐HAART eras. The polymorphisms of interferon (IFN)‐λ4 have been postulated as possibly associated with the pathogenesis of HIV infection. The aim of this study was to describe the incidence and mortality from a cohort of HIV‐positive patients as well as whether IFN‐λ4 gene polymorphisms (SNP rs8099917 and SNP rs12979860) were associated with HIV/acquired immune deficiency syndrome (AIDS) progression. We followed 402 patients for up to 30 years; 347 of them began follow‐up asymptomatic, without any AIDS‐defining opportunistic disease and/or a lymphocytes T CD4+ count of 350 cells/mm 3 or lower. We determined the probability of the asymptomatic subjects to remain AIDS‐free, and the risk of death for those entering the study already with an AIDS diagnosis, as well as for subjects developing AIDS during follow‐up. We compared the prognosis of patients with two different polymorphisms for the genes encoding for IFN‐λ4, variants rs8099917 and rs12979860. The follow‐up time of the 347 asymptomatic‐at‐entry subjects was 3687 person‐years. IFN‐λ4 rs8099917 polymorphisms were not associated with AIDS progression, but IFN‐λ4 rs12979860 wild type genotype (CC) was associated with higher mortality compared to CT and TT, with an increased probability of death from AIDS ( P = .01). In conclusion, genetic variations in IFN‐λ4 on rs12979860 polymorphisms in HIV‐infected patients may drive mortality risk. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/jmv.26054 |
| الاتاحة: | http://dx.doi.org/10.1002/jmv.26054 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fjmv.26054 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jmv.26054 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/jmv.26054 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.FAB50D8A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/jmv.26054 |
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