Academic Journal
Spectral parameters modulation and source localization of blink-related alpha and low-beta oscillations differentiate minimally conscious state from vegetative state/unresponsive wakefulness syndrome
| العنوان: | Spectral parameters modulation and source localization of blink-related alpha and low-beta oscillations differentiate minimally conscious state from vegetative state/unresponsive wakefulness syndrome |
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| المؤلفون: | Bonfiglio, Luca, Piarulli, Andrea, Olcese, Umberto, ANDRE, PAOLO, Arrighi, Pieranna, Frisoli, Antonio, Rossi, Bruno, Bergamasco, Massimo, Carboncini, Maria Chiara |
| المساهمون: | Bonfiglio, Luca, Piarulli, Andrea, Olcese, Umberto, Andre, Paolo, Arrighi, Pieranna, Frisoli, Antonio, Rossi, Bruno, Bergamasco, Massimo, Carboncini, Maria Chiara |
| سنة النشر: | 2014 |
| المجموعة: | Università degli Studi di Siena: USiena air |
| مصطلحات موضوعية: | Brain damaged patient, default mode network, electromagnetic tomography, resting state, different reference, object recognition, delta oscillations, infinity reference, EEG |
| الوصف: | Recently, the cortical source of blink-related delta oscillations (delta BROs) in resting healthy subjects has been localized in the posterior cingulate cortex/precuneus (PCC/PCu), one of the main core-hubs of the default-mode network. This has been interpreted as the electrophysiological signature of the automatic monitoring of the surrounding environment while subjects are immersed in self-reflecting mental activities. Although delta BROs were directly correlated to the degree of consciousness impairment in patients with disorders of consciousness, they failed to differentiate vegetative state/unresponsive wakefulness syndrome (VS/UWS) from minimally conscious state (MCS). In the present study, we have extended the analysis of BROs to frequency bands other than delta in the attempt to find a biological marker that could support the differential diagnosis between VS/UWS and MCS. Four patients with VS/UWS, 5 patients with MCS, and 12 healthy matched controls (CTRL) underwent standard 19-channels EEG recordings during resting conditions. Three-second-lasting EEG epochs centred on each blink instance were submitted to time-frequency analyses in order to extract the normalized Blink-Related Synchronization/Desynchronization (nBRS/BRD) of three bands of interest (low-alpha, high-alpha and low-beta) in the time-window of 50-550 ms after the blink-peak and to estimate the corresponding cortical sources of electrical activity. VS/UWS nBRS/BRD levels of all three bands were lower than those related to both CTRL and MCS, thus enabling the differential diagnosis between MCS and VS/UWS. Furthermore, MCS showed an intermediate signal intensity on PCC/PCu between CTRL and VS/UWS and a higher signal intensity on the left temporo-parieto-occipital junction and inferior occipito-temporal regions when compared to VS/UWS. This peculiar pattern of activation leads us to hypothesize that resting MCS patients have a bottom-up driven activation of the task positive network and thus are tendentially prone to respond to environmental ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/24676098; info:eu-repo/semantics/altIdentifier/wos/WOS:000333677500098; volume:9; issue:3; firstpage:1; lastpage:16; numberofpages:16; journal:PLOS ONE; http://hdl.handle.net/11365/974279; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84899747936; http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.pone.0093252&representation=PDF |
| DOI: | 10.1371/journal.pone.0093252 |
| DOI: | 10.1371/journal.pone.0093252&representation=PDF |
| الاتاحة: | http://hdl.handle.net/11365/974279 https://doi.org/10.1371/journal.pone.0093252 http://www.plosone.org/article/fetchObject.action?uri=info:doi/10.1371/journal.pone.0093252&representation=PDF |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.FA3BD47B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0093252 |
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