Academic Journal
PTMselect: optimization of protein modifications discovery by mass spectrometry
| العنوان: | PTMselect: optimization of protein modifications discovery by mass spectrometry |
|---|---|
| المؤلفون: | Perchey, Renaud T., Tonini, Laure, Tosolini, Marie, Fournié, Jean-Jacques, Lopez, Frédéric, Besson, Arnaud, Pont, Frédéric |
| المصدر: | Scientific Reports ; volume 9, issue 1 ; ISSN 2045-2322 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2019 |
| الوصف: | Discovery of protein modification sites relies on protein digestion by proteases and mass spectrometry (MS) identification of the modified peptides. Depending on proteases used and target protein sequence, this method yields highly variable coverage of modification sites. We introduce PTMselect, a digestion-simulating software which tailors the optimal set of proteases for discovery of global or targeted modification from any single or multiple proteins. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41598-019-40873-3 |
| الاتاحة: | http://dx.doi.org/10.1038/s41598-019-40873-3 https://www.nature.com/articles/s41598-019-40873-3.pdf https://www.nature.com/articles/s41598-019-40873-3 |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.FA2D51EF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-019-40873-3 |
|---|