Academic Journal
Complex genomic rearrangements lead to novel primate gene function
| العنوان: | Complex genomic rearrangements lead to novel primate gene function |
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| المؤلفون: | Ciccarelli, F.D., von Mering, C., Suyama, M., Harrington, E.D., Izaurralde, E., Bork, P. |
| بيانات النشر: | Cold Spring Harbor Laboratory Press |
| سنة النشر: | 2005 |
| المجموعة: | Max-Delbrueck-Center for Molecular Medicine, Berlin: MDC Repository |
| مصطلحات موضوعية: | Cardiovascular and Metabolic Diseases |
| الوصف: | Orthologous genes that maintain a single-copy status in a broad range of species may indicate a selection against gene duplication. If this is the case, then duplicates of such genes that do survive may have escaped the dosage control by rapid and sizable changes in their function. To test this hypothesis and to develop a strategy for the identification of novel gene functions, we have analyzed 22 primate-specific intrachromosomal duplications of genes with a single-copy ortholog in all other completely sequenced metazoans. When comparing this set to genes not exposed to the single-copy status constraint, we observed a higher tendency of the former to modify their gene structure, often through complex genomic rearrangements. The analysis of the most dramatic of these duplications, affecting ∼10% of human Chromosome 2, enabled a detailed reconstruction of the events leading to the appearance of a novel gene family. The eight members of this family originated from the highly conserved nucleoporin RanBP2 by several genetic rearrangements such as segmental duplications, inversions, translocations, exon loss, and domain accretion. We have experimentally verified that at least one of the newly formed proteins has a cellular localization different from RanBP2's, and we show that positive selection did act on specific domains during evolution. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://edoc.mdc-berlin.de/7665/1/7665oa.pdf; Complex genomic rearrangements lead to novel primate gene function. Ciccarelli, F.D. and von Mering, C. and Suyama, M. and Harrington, E.D. and Izaurralde, E. and Bork, P. Genome Research 15 (3): 343-351. 1 January 2005 |
| DOI: | 10.1101/gr.3266405 |
| الاتاحة: | http://edoc.mdc-berlin.de/7665/ https://edoc.mdc-berlin.de/7665/ http://edoc.mdc-berlin.de/7665/1/7665oa.pdf https://doi.org/10.1101/gr.3266405 |
| رقم الانضمام: | edsbas.FA18C10D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1101/gr.3266405 |
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