التفاصيل البيبلوغرافية
| العنوان: |
Ring-extended gramicidin S analogs Containing cis δ-sugar amino acid turn mimetics with varying ring size |
| المؤلفون: |
Knijnenburg, A.D., Spalburg, E., Neeling, A.J. de, Mars-Groenendijk, R.H., Noort, D., Grotenbreg, G.M., Marel, G.A. van der, Overkleeft, H.S., Overhand, M. |
| المصدر: |
Helvetica Chimica Acta, 12, 95, 2544-2561 |
| سنة النشر: |
2012 |
| المجموعة: |
TU Delft: Institutional Repository (Delft University of Technology) |
| مصطلحات موضوعية: |
Antimicrobial activity, Conformational analysis, Gramicidin S, Peptides, Anti-microbial activity, Mimetics, Oxetanes, Protonated, Ring sizes, Side-chains, Sugar amino acids, Sugars, Amino acids, Amino acid, Furan derivative, Gramicidin derivative, Gramicidin s derivative, Hemolytic agent, Ornithine, Oxetane derivative, Pyran derivative, Unclassified drug, Antibacterial activity, Biomimetics, Controlled study, Drug synthesis, Gram negative bacterium, Gram positive bacterium, Hmolysis, Human |
| الوصف: |
This article presents a series of ring-extended gramicidin S derivatives, 9-14, that have four ornithine residues as polar protonated side chains and one modified turn region containing a mono-functionalized cis-δ-oxetane, δ-furanoid, or δ-pyranoid sugar amino acid residue. Of the GS analogs evaluated, we identified compound 7, which contains the mono-benzyloxy cis-δ-pyranoid sugar amino acid, as having a better biological profile than the clinically applied topical antibiotic gramicidin S. Copyright © 2012 Verlag Helvetica Chimica Acta AG, Zürich, Switzerland. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| Relation: |
uuid:5b1f7a7d-243b-4624-9a73-1ece82d378c5; 470048; http://resolver.tudelft.nl/uuid:5b1f7a7d-243b-4624-9a73-1ece82d378c5 |
| الاتاحة: |
http://resolver.tudelft.nl/uuid:5b1f7a7d-243b-4624-9a73-1ece82d378c5 |
| رقم الانضمام: |
edsbas.F9F8E674 |
| قاعدة البيانات: |
BASE |