Academic Journal
Mediterranean diet food components as possible adjuvant therapies to counteract breast and prostate cancer progression to bone metastasis
| العنوان: | Mediterranean diet food components as possible adjuvant therapies to counteract breast and prostate cancer progression to bone metastasis |
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| المؤلفون: | Maroni P., Bendinelli P., Fulgenzi A., Ferraretto A. |
| المساهمون: | P. Maroni, P. Bendinelli, A. Fulgenzi, A. Ferraretto |
| بيانات النشر: | MDPI |
| سنة النشر: | 2021 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | bone metastasi, breast cancer, epithelial–mesenchymal transition, Mediterranean diet, nutrient, osteoblastic bone metastasi, osteolytic bone metastasi, prostate cancer, bone neoplasm, breast neoplasm, female, human, male, prostatic neoplasm, chemotherapy, adjuvant, diet, Mediterranean, disease progression, food, Settore MED/04 - Patologia Generale, Settore MED/49 - Scienze Tecniche Dietetiche Applicate |
| الوصف: | Bone metastasis is a serious and often lethal complication of particularly frequent carcinomas, such as breast and prostate cancers, which not only reduces survival but also worsens the patients’ quality of life. Therefore, it is important to find new and/or additional therapeutic possibilities that can counteract the colonization of bone tissue. High adherence to the Mediterranean diet (MD) is effective in the prevention of cancer and improves cancer patients’ health, thus, here, we considered its impact on bone metastasis. We highlighted some molecular events relevant for the development of a metastatic phenotype in cancer cells and the alterations of physiological bone remodeling, which occur during skeleton colonization. We then considered those natural compounds present in MD foods with a recognized role to inhibit or reverse the metastatic process both in in vivo and in vitro systems, and we reported the identified mechanisms of action. The knowledge of this bioactivity by the dietary components of the MD, together with its wide access to all people, could help not only to maintain healthy status but also to improve the quality of life of patients with bone metastases. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/34572548; info:eu-repo/semantics/altIdentifier/wos/WOS:000699079600001; volume:11; issue:9; firstpage:1; lastpage:18; numberofpages:18; journal:BIOMOLECULES; http://hdl.handle.net/2434/898484; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85114521659 |
| DOI: | 10.3390/biom11091336 |
| الاتاحة: | http://hdl.handle.net/2434/898484 https://doi.org/10.3390/biom11091336 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.F9F88B42 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/biom11091336 |
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