Academic Journal
In Vitro Activities of 21 Antimicrobial Agents Alone and in Combination with Aminoglycosides or Fluoroquinolones against Extended-Spectrum-β-Lactamase-Producing Escherichia coli Isolates Causing Bacteremia
| العنوان: | In Vitro Activities of 21 Antimicrobial Agents Alone and in Combination with Aminoglycosides or Fluoroquinolones against Extended-Spectrum-β-Lactamase-Producing Escherichia coli Isolates Causing Bacteremia |
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| المؤلفون: | Cha, Min Kyeong, Kang, Cheol-In, Kim, So Hyun, Cho, Sun Young, Ha, Young Eun, Wi, Yu Mi, Chung, Doo Ryeon, Peck, Kyong Ran, Song, Jae-Hoon |
| المصدر: | Antimicrobial Agents and Chemotherapy ; volume 59, issue 9, page 5834-5837 ; ISSN 0066-4804 1098-6596 |
| بيانات النشر: | American Society for Microbiology |
| سنة النشر: | 2015 |
| الوصف: | We evaluated the in vitro activity of various antimicrobials alone and in combination against 291 extended-spectrum-β-lactamase-producing Escherichia coli (ESBL-EC) isolates causing bacteremia in South Korean hospitals. Ceftazidime, cefepime, and piperacillin-tazobactam in combination with amikacin showed greater activity than found in combination with ciprofloxacin. In settings with a high prevalence of ESBL-producing pathogens, combination aminoglycoside antimicrobial therapy, especially with amikacin, may be considered for empirical therapy against suspected Gram-negative sepsis as a carbapenem-saving strategy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1128/aac.01121-15 |
| DOI: | 10.1128/AAC.01121-15 |
| الاتاحة: | http://dx.doi.org/10.1128/aac.01121-15 https://journals.asm.org/doi/pdf/10.1128/AAC.01121-15 |
| Rights: | https://journals.asm.org/non-commercial-tdm-license |
| رقم الانضمام: | edsbas.F9F0EBA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1128/aac.01121-15 |
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