Academic Journal
Proliferative glomerulonephritis with monoclonal IgG Lambda deposits caused by plasmablastic lymphoma: a case report
| العنوان: | Proliferative glomerulonephritis with monoclonal IgG Lambda deposits caused by plasmablastic lymphoma: a case report |
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| المؤلفون: | Ren, Ling-Yan, Chen, Qi, Qiu, Feng-Ping, Jiang, Zhen-Yu, Wang, Xiao-Yi, Zhang, Xiao-Lan, Shi, Zhan-Qin |
| المساهمون: | Zhejiang Medical and Health Science and Technology Project, Huzhou Municipal Science and Technology Bureau Public Welfare Application Research Project |
| المصدر: | BMC Nephrology ; volume 24, issue 1 ; ISSN 1471-2369 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2023 |
| الوصف: | Introduction As a very rare form of B-cell lymphoma, plasmablastic lymphoma (PBL) typically occurs in patients with underlying immunosuppression, including human immunodeficiency virus (HIV), organ transplantation, and autoimmune diseases. For HIV-positive patients, PBL normally originates in the gastrointestinal tract, especially from the oral cavity in most cases. It is extremely rare to find abdominal cavity involvement in PBL, and there has been no previously reported instance of proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) attributed to monoclonal IgG (MIgG) lambda secreted by PBL. Case presentation We report the case of an HIV-negative female with nephrotic syndrome, renal insufficiency, and multiple swollen lymph nodes. Ascitic fluid cytology revealed a high level of plasmablast-like lymphocytes with the restriction of lambda light chains. Besides, the renal biopsy revealed PGNMID, which could presumably be secondary to MIgG-lambda-secreting by PBL. MIgG-lambda-restricted expression was discovered earlier in the kidney tissue than in the blood. Conclusion The diagnostic landscape for PBL is notoriously intricate, necessitating a multifaceted and nuanced approach to mitigate the risks of erroneous identification. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1186/s12882-023-03351-7 |
| DOI: | 10.1186/s12882-023-03351-7.pdf |
| DOI: | 10.1186/s12882-023-03351-7/fulltext.html |
| الاتاحة: | http://dx.doi.org/10.1186/s12882-023-03351-7 https://link.springer.com/content/pdf/10.1186/s12882-023-03351-7.pdf https://link.springer.com/article/10.1186/s12882-023-03351-7/fulltext.html |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.F9DBD632 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12882-023-03351-7 |
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