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Adenomyomas of the gallbladder: An analysis of frequency, clinicopathologic associations, and relationship to carcinoma of a malformative lesion

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العنوان: Adenomyomas of the gallbladder: An analysis of frequency, clinicopathologic associations, and relationship to carcinoma of a malformative lesion
المؤلفون: Dursun, Nevra, Memiş, Bahar, Taşkın, Orhun Çiğ, Okcu, Oğuzhan, Akkaş, Gizem, Bağcı, Pelin, Balcı, Serdar, Saka, Burcu, Araya, Juan Carlos, Bellolio, Enrique, Roa, Juan Carlos, Jang, Kee-Taek, Losada, Hector, Maithel, Shishir K., Sarmiento, Juan, Reid, Michelle D., Jang, JinYoung, Cheng, Jeanette D., Baştürk, Olca, Koshiol, Jill, Adsay, N. Volkan
المساهمون: RTEÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Okcu, Oğuzhan
سنة النشر: 2023
الوصف: Context.—The nature and associations of gallbladder (GB) ‘‘adenomyoma’’ (AM) remain controversial. Some studies have attributed up to 26% of GB carcinoma to AMs. Objective.—To examine the true frequency, clinicopathologic characteristics, and neoplastic changes in GB AM. Design.—Cholecystectomy cohorts analyzed were 1953 consecutive cases, prospectively with specific attention to AM; 2347 consecutive archival cases; 203 totally embedded GBs; 207 GBs with carcinoma; and archival search of institutions for all cases diagnosed as AM. Results.—Frequency of AM was 9.3% (19 of 203) in totally submitted cases but 3.3% (77 of 2347) in routinely sampled archival tissue. A total of 283 AMs were identified, with a female to male ratio ¼ 1.9 (177:94) and mean size ¼ 1.3 cm (range, 0.3–5.9). Most (96%, 203 of 210) were fundic, with formed nodular trabeculated submucosal thickening, and were difficult to appreciate from the mucosal surface. Four of 257 were multifocal (1.6%), and 3 of 257 (1.2%) were extensive (‘‘adenomyomatosis’’). Dilated glands (up to 14 mm), often radially converging to a point in the mucosa, were typical. Muscle was often minimal, confined to the upper segment. Nine of 225 (4%) revealed features of a duplication. No specific associations with inflammation, cholesterolosis, intestinal metaplasia, or thickening of the uninvolved GB wall were identified. Neoplastic change arising in AM was seen in 9.9% (28 of 283). Sixteen of 283 (5.6%) had mural intracholecystic neoplasm; 7 of 283 (2.5%) had flat-type high-grade dysplasia/carcinoma in situ. Thirteen of 283 cases had both AM and invasive carcinoma (4.6%), but in only 5 of 283 (1.8%), carcinoma was arising from AM (invasion was confined to AM, and dysplasia was predominantly in AM). Conclusions.—AMs have all the features of a malformative developmental lesion, and may not show a significant muscle component; (ie, the name ‘‘adeno-myoma’’ is partly a misnomer). While most are innocuous, some pathologies may arise in AMs, including intracholecystic neoplasms, ...
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: English
تدمد: 0003-9985
1543-2165
Relation: Archives of Pathology & Laboratory Medicine; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; Dursun, N., Memis, B., Pehlivanoglu, B., Taskin, O. C., Okcu, O., Akkas, G., Bagci, P., Balci, S., Saka, B., Araya, J. C., Bellolio, E., Roa, J. C., Jang, K. T., Losada, H., Maithel, S. K., Sarmiento, J., Reid, M. D., Jang, J., Cheng, J. D., Basturk, O., … Adsay, N. V. (2023). Adenomyomas of the Gallbladder: An Analysis of Frequency, Clinicopathologic Associations, and Relationship to Carcinoma of a Malformative Lesion. Archives of pathology & laboratory medicine, 10.5858/arpa.2022-0379-OA. Advance online publication. https://doi.org/10.5858/arpa.2022-0379-OA; https://doi.org/10.5858/arpa.2022-0379-OA; https://hdl.handle.net/11436/8582
DOI: 10.5858/arpa.2022-0379-OA
الاتاحة: https://hdl.handle.net/11436/8582
https://doi.org/10.5858/arpa.2022-0379-OA
Rights: info:eu-repo/semantics/openAccess
رقم الانضمام: edsbas.F9742E4
قاعدة البيانات: BASE
الوصف
تدمد:00039985
15432165
DOI:10.5858/arpa.2022-0379-OA