Academic Journal
Schistogram changes after administration of antischistosomal drugs in mice at the early phase of Schistosoma mansoni infection
| العنوان: | Schistogram changes after administration of antischistosomal drugs in mice at the early phase of Schistosoma mansoni infection |
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| المؤلفون: | Vimieiro, Andréa Cássia Simões, Araújo, Neusa, Katz, Naftale, Kusel, John Robert, Coelho, Paulo Marcos Zech |
| بيانات النشر: | Instituto Oswaldo Cruz |
| سنة النشر: | 2013 |
| المجموعة: | University of Glasgow: Enlighten - Publications |
| الوصف: | Mice infected with Schistosoma mansoni were treated with oxamniquine, praziquantel, artesunate at the pre-patent phase, aiming at observing schistogram alterations. Half of the animals were perfused five days post-treatment for counting and classification of immature worms, based on pre-established morphological criteria (schistogram); the remaining animals were evaluated 42 or 100 days after infection and perfusion of the portal-system was performed for collection and counting of adult worms and oogram. It was observed that oxamniquine and artesunate treatment administered at the pre-postural phase causes significant reduction in the number of immature and adult worms. However, there was little reduction with praziquantel when used at the dose of 400 mg/kg for treatments administered 14, 15, 21 or 23 days post-infection. Artesunate was responsible for significant alterations in development of young worms, as well as for a higher number of worms presenting intestinal damages. Immature adult worms were detected in mice treated with artesunate or oxamniquine at the pre-patent phase of infection and recovered by perfusion 100 days after infection. Schistogram proved to be a very useful tool for experimental evaluation of the activity of antischistosomal drugs and a good model to identify the most sensitive stages to drugs. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | http://eprints.gla.ac.uk/141737/1/141737.pdf; Vimieiro, A. C. S., Araújo, N., Katz, N., Kusel, J. R. and Coelho, P. M. Z. (2013) Schistogram changes after administration of antischistosomal drugs in mice at the early phase of Schistosoma mansoni infection. Memorias Do Instituto Oswaldo Cruz , 108(7), pp. 881-886. (doi:10.1590/0074-0276130135 ) (PMID:24271044) (PMCID:PMC3970651) |
| الاتاحة: | http://eprints.gla.ac.uk/141737/ http://eprints.gla.ac.uk/141737/1/141737.pdf |
| Rights: | cc_by_nc |
| رقم الانضمام: | edsbas.F95A593F |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |