Academic Journal
Incident Dementia in Elderly Patients with Nonalcoholic Fatty Liver Disease in Germany
| العنوان: | Incident Dementia in Elderly Patients with Nonalcoholic Fatty Liver Disease in Germany |
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| المؤلفون: | Labenz, Christian, Kostev, Karel, Kaps, Leonard, Galle, Peter R., Schattenberg, Jörn M. |
| المصدر: | http://lobid.org/resources/99370675664106441#!, 66(9):3179-3185. |
| سنة النشر: | 2020 |
| المجموعة: | Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: | Aged [MeSH], Dementia/diagnosis [MeSH], Risk Factors [MeSH], Germany/epidemiology [MeSH], Original Article, Metabolism [MeSH], Aging, Male [MeSH], Risk Assessment/methods [MeSH], Aging/physiology [MeSH], Non-alcoholic Fatty Liver Disease/epidemiology [MeSH], Cognitive impairment, Dementia/epidemiology [MeSH], Cognitive Aging/physiology [MeSH], Female [MeSH], Humans [MeSH], Non-alcoholic Fatty Liver Disease/metabolism [MeSH], Incidence [MeSH], Non-alcoholic Fatty Liver Disease/diagnosis [MeSH], Retrospective Studies [MeSH], Metabolic inflammation, Cognitive decline, Aging/psychology [MeSH], Brain/metabolism [MeSH], Database research study, Dementia/metabolism [MeSH], Causality [MeSH] |
| الوصف: | Dementia and NAFLD are two frequent conditions that share underlying risk factors mainly in the realm of metabolic disease. Additionally, an association between NAFLD and brain aging has been proposed. Therefore, we investigated the hypothesis if NAFLD is an independent risk factor for emerging dementia. In this population-based cohort study, elderly patients (≥ 65 years) with NAFLD diagnosed between 2000 and 2015 were matched 1:1 to a cohort without NAFLD based on ICD-10 coding in the Disease Analyzer database. Matching criteria were age, sex, physician, index year, and co-diagnoses associated with dementia. The primary outcomes of this study were all-cause dementia diagnoses, the incidence of vascular dementia, and antidementive drug prescription. A total of 22,317 patients with NAFLD were matched to 22,317 patients without NAFLD. Within 10 years of the index date, 16.0% of patients with NAFLD and 15.6% of the patients without NAFLD were diagnosed with dementia. On Cox regression analysis, there is no association between NAFLD and the incidence of all-cause dementia (HR 0.97, 95% CI 0.92-1.04), vascular dementia (HR 0.89, 95% CI 0.78-1.02), or the new prescription of antidementive therapy (HR 0.87, 95% CI 0.76-1.01). In sensitivity analyses, there was no association between NAFLD and dementia in different age-groups as well as men or women. In conclusion, in this database study of elderly patients coded with NAFLD no independent association with incident dementia was detected. Risk assessment regarding dementia in patients with NAFLD should be carried out in the same way as for metabolic burdened patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://repository.publisso.de/resource/frl:6465047; https://doi.org/10.1007/s10620-020-06644-1; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379104/ |
| DOI: | 10.1007/s10620-020-06644-1 |
| الاتاحة: | https://repository.publisso.de/resource/frl:6465047 https://doi.org/10.1007/s10620-020-06644-1 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8379104/ |
| Rights: | https://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.F957B0D4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s10620-020-06644-1 |
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