Academic Journal
Nanotechnology connecting copper metabolism and tumor therapy
| العنوان: | Nanotechnology connecting copper metabolism and tumor therapy |
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| المؤلفون: | Li, Yongjuan, Dong, Ya, Zhou, Xinyao, Fan, Kelong |
| المساهمون: | National Natural Science Foundation of China |
| المصدر: | MedComm – Biomaterials and Applications ; volume 2, issue 2 ; ISSN 2769-643X 2769-643X |
| بيانات النشر: | Wiley |
| سنة النشر: | 2023 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Copper (Cu) is an essential trace element in the human body that is involved in the formation of several natural enzymes, such as superoxide dismutase and cyclooxygenase. Due to the high density of the outer electron cloud of Cu, which allows the transfer of multiple electrons, Cu is often used as the catalytic center in various metabolic enzymes. However, both deficiency and excessive accumulation of Cu can result in irreversible damage to cells. Therefore, strategies to regulate Cu metabolism, such as Cu exhaustion and Cu supplementation, have emerged as attractive approaches in anticancer therapy, due to the potential damages caused by Cu metabolism disorders. Notably, recent advancements in nanotechnology have enabled the development of nanomaterials that can regulate Cu metabolism, making this therapy applicable in vivo. In this review, we provide a systematic discussion of the physical and chemical properties of Cu and summarize the applications of nanotechnology in Cu metabolism‐based antitumor therapy. Finally, we outline the future directions and challenges of nano‐Cu therapy, emphasizing the scientific problems and technical bottlenecks that need to be addressed for successful clinical translation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/mba2.36 |
| الاتاحة: | http://dx.doi.org/10.1002/mba2.36 https://onlinelibrary.wiley.com/doi/pdf/10.1002/mba2.36 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.F8EA6924 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/mba2.36 |
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