Academic Journal
Effect of Vitamin K 1 Supplementation on Vitamin K Status in Cystic Fibrosis Patients
| العنوان: | Effect of Vitamin K 1 Supplementation on Vitamin K Status in Cystic Fibrosis Patients |
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| المؤلفون: | Beker, Leila T., Ahrens, Richard A., Fink, Robert J., O'Brien, Maureen E., Davidson, Kenneth W., Sokoll, Lori J., Sadowski, James A. |
| المصدر: | Journal of Pediatric Gastroenterology and Nutrition ; volume 24, issue 5, page 512-517 ; ISSN 0277-2116 1536-4801 |
| بيانات النشر: | Wiley |
| سنة النشر: | 1997 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Background: Patients with cystic fibrosis are at risk for impaired vitamin K status due to fat malabsorption from pancreatic insufficiency. This study was designed to assess vitamin K status and measure the effect of vitamin K 1 supplementation in cystic fibrosis patients. Methods: Eighteen outpatients participated in a crossover study to determine the effect of vitamin K 1 (phylloquinone) supplementation. After obtaining initial data, each subject was randomly assigned to either a 4‐week study treatment of 5 mg oral vitamin K 1 supplementation per week, or no supplementation and then crossed over to the other treatment for a second 4 week period. Plasma, serum and urine samples were collected and analyzed pre‐study and at the end of each study period. Results: The mean concentration of plasma vitamin K 1 for the supplemented group was significantly higher than the unsupplemented group, [0.34 nmol/L and 0.21 nmol/L, respectively ( p < 0.05)]. The percent of undercarboxylated osteocalcin increased on supplementation from 17% to 31%, ( p < 0.005). Prothrombin induced in vitamin K absence (PIVKA‐II) increased on supplementation from 5 ng/mL to 22 ng/mL, ( p < 0.005). The ratio of urinary gammacarboxyglutamic acid/creatinine was similar for both study periods. Conclusions: In contrast to other studies in cystic fibrosis, this study demonstrated a need for vitamin K 1 supplementation. The carboxylation state of osteocalcin and PIVKA‐II were the most sensitive indices of changes in vitamin K 1 status. Although the 5 mg vitamin K 1 /week dose improved these vitamin K parameters, normal levels were not achieved. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/j.1536-4801.1997.tb00641.x |
| الاتاحة: | http://dx.doi.org/10.1002/j.1536-4801.1997.tb00641.x https://onlinelibrary.wiley.com/doi/full/10.1002/j.1536-4801.1997.tb00641.x |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.F883526A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/j.1536-4801.1997.tb00641.x |
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