Academic Journal
Prevalence of C-reactive protein elevation and time course of normalization in acute pericarditis: Implications for the diagnosis, therapy, and prognosis of pericarditis
| العنوان: | Prevalence of C-reactive protein elevation and time course of normalization in acute pericarditis: Implications for the diagnosis, therapy, and prognosis of pericarditis |
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| المؤلفون: | Imazio M., Brucato A., Maestroni S., Cumetti D., Dominelli A., Natale G., Trinchero R. |
| المساهمون: | M. Imazio, A. Brucato, S. Maestroni, D. Cumetti, A. Dominelli, G. Natale, R. Trinchero |
| سنة النشر: | 2011 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | C-reactive protein, diagnosi, pericarditi, prognosi, therapy, Settore MED/09 - Medicina Interna |
| الوصف: | Background-The role of inflammatory markers is not well defined for either diagnosis or treatment of pericarditis. The aim of this study is to prospectively evaluate the frequency of high-sensitivity C-reactive protein (hs-CRP) elevation in patients with acute pericarditis, its time course of normalization, and the possible importance for diagnosis, therapy, and prognosis. Methods and Results-Two hundred consecutive patients with viral or idiopathic acute pericarditis (mean age, 53 +/- 15.5 years; 103 men) were studied from August 2005 to August 2007 in 2 Italian referral centers. Hs-CRP was determined at presentation and then every week until normalization. Hs-CRP elevation was recorded in 156 of 200 cases (78%) at presentation. Recognized causes of a negative hs-CRP at presentation were early assessment in 15 of 44 cases (34%) and previous anti-inflammatory therapies in 22 of 44 cases (50%). Hs-CRP normalization was achieved with the following time course: 120 of 200 (60%) at week 1, 170 of 200 (85%) at week 2, 190 of 200 (95%) at week 3, and all cases (100%) at week 4. In multivariable analysis, incomplete response to empirical anti-inflammatory therapy at week 1 (hazard ratio, 2.98; 95% confidence interval, 1.80 to 4.94; P < 0.001), corticosteroid therapy (hazard ratio, 2.80; 95% confidence interval, 1.59 to 4.95; P < 0.001), and the presence of elevated hs-CRP at week 1 (hazard ratio, 2.36; 95% confidence interval, 1.32 to 4.21; P=0.004) were independent risk factors for recurrence. Conclusions-Hs-CRP is elevated at the initial presentation in approximate to 3 of 4 cases of acute pericarditis, identifies patients at higher risk of recurrence, and could be used to monitor disease activity and select appropriate therapy length. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/21357824; info:eu-repo/semantics/altIdentifier/wos/WOS:000288369900014; volume:123; issue:10; firstpage:1092; lastpage:1097; numberofpages:6; journal:CIRCULATION; http://hdl.handle.net/2434/635670; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-79953051127 |
| DOI: | 10.1161/CIRCULATIONAHA.110.986372 |
| الاتاحة: | http://hdl.handle.net/2434/635670 https://doi.org/10.1161/CIRCULATIONAHA.110.986372 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.F85926F6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1161/CIRCULATIONAHA.110.986372 |
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