Academic Journal
The mouse vitronectin receptor is a T cell activation antigen.
| العنوان: | The mouse vitronectin receptor is a T cell activation antigen. |
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| المؤلفون: | Moulder, K, Roberts, K, Shevach, E M, Coligan, J E |
| المصدر: | The Journal of experimental medicine ; volume 173, issue 2, page 343-347 ; ISSN 0022-1007 1540-9538 |
| بيانات النشر: | Rockefeller University Press |
| سنة النشر: | 1991 |
| الوصف: | In this report, we demonstrate that the T cell activation antigen, recognized by monoclonal antibody H9.2B8, is the murine homologue of the vitronectin receptor (VNR) and, thereby, we provide initial evidence that VNR is expressed on lymphoid cells. VNR is expressed on a variety of T cell lines, tumors, and Con A-activated splenocytes, but not resting T cells, and is capable of binding to the extracellular matrix proteins fibronectin, fibrinogen, and vitronectin, via the tripeptide sequence RGD. There was no evidence of novel beta chains pairing with the VNR alpha chain, as has been demonstrated in some human cells. In view of recent studies demonstrating that this molecule functions as an accessory molecule in T cell activation, the VNR may play an important role in mouse T cell functions. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1084/jem.173.2.343 |
| الاتاحة: | http://dx.doi.org/10.1084/jem.173.2.343 https://rupress.org/jem/article-pdf/173/2/343/1672024/343.pdf |
| رقم الانضمام: | edsbas.F7DD9D38 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1084/jem.173.2.343 |
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