Academic Journal
The Relationship Between Angiotensinogen Gene Polymorphisms and Essential Hypertension in a Northern Han Chinese Population
| العنوان: | The Relationship Between Angiotensinogen Gene Polymorphisms and Essential Hypertension in a Northern Han Chinese Population |
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| المؤلفون: | Li, Hongmei, Du, Zhirong, Zhang, Lin, Wu, Tong, Deng, Zhihui, Li, Jingping, Cong, Mingyu, Liu, Jicheng, Qiu, Changchun |
| المصدر: | Angiology ; volume 65, issue 7, page 614-619 ; ISSN 0003-3197 1940-1574 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2013 |
| الوصف: | Gene polymorphisms of the renin–angiotensin system are involved in the pathophysiology of hypertension. We genotyped 4 polymorphisms of angiotensinogen (AGT) gene A-20C (rs5050), A-6G (rs5051), C3889T (rs4762), and C4072T (rs699) by polymerase chain reaction-restriction fragment length polymorphism in 652 patients and 780 controls to examine the association of AGT and hypertension in a Northern Han Chinese population. There were significant differences in the distribution of genotypes and allele frequencies at C4072T between the patients and the controls (both P < .01); patients with CC genotype had a higher risk of hypertension (odds ratio = 1.7, 95% confidence interval 1.4–2.1). The distribution of genotypes at A-6G was significantly different between patients and controls ( P < .05). No other significant differences in genotypes or frequencies were observed. No association was observed between the haplotypes of AGT and hypertension. The AGT-6A and 4072C alleles are associated with susceptibility to hypertension in this population. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/0003319713491309 |
| الاتاحة: | https://doi.org/10.1177/0003319713491309 https://journals.sagepub.com/doi/pdf/10.1177/0003319713491309 https://journals.sagepub.com/doi/full-xml/10.1177/0003319713491309 |
| Rights: | https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| رقم الانضمام: | edsbas.F7DBFC53 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/0003319713491309 |
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