Academic Journal
Chemical Information Processing by a Responsive Chemical System
| العنوان: | Chemical Information Processing by a Responsive Chemical System |
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| المؤلفون: | Luca Gabrielli, Lorenzo Goldin, Sushmitha Chandrabhas, Andrea Dalla Valle, Leonard J. Prins |
| سنة النشر: | 1753 |
| مصطلحات موضوعية: | Biophysics, Biochemistry, Neuroscience, Evolutionary Biology, Ecology, Immunology, Inorganic Chemistry, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, process information arriving, monophosphate nucleosides act, low micromolar concentrations, external stimuli lead, allow likewise control, highly complex mixture, chemical information processing, upregulate chemical reactions, synthetic chemical systems, chemical reactivity occurs, chemical reactivity, chemical reactions, chemical triggers, thus establishing, take place, synthetic system, precisely regulate, limited amount, initial steps, induced upregulation, gradually removed |
| الوصف: | Nature has an extraordinary capacity to precisely regulate the chemical reactivity in a highly complex mixture of molecules that is present in the cell. External stimuli lead to transient up- and downregulation of chemical reactions and provide a means for a cell to process information arriving from the environment. The development of synthetic chemical systems with life-like properties requires strategies that allow likewise control over chemical reactivity in a complex environment. Here, we show a synthetic system that mimics the initial steps that take place when a natural signal transduction pathway is activated. Monophosphate nucleosides act as chemical triggers for the self-assembly of nanoreactors that upregulate chemical reactions between reagents present at low micromolar concentrations. Different nucleotides template different assemblies and hence activate different pathways, thus establishing a distinct connection between input and output molecules. Trigger-induced upregulation of chemical reactivity occurs for only a limited amount of time because the chemical triggers are gradually removed from the system by enzymes. It is shown that the same system transiently produces different output molecules depending on the chemical input that is provided. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/journal_contribution/Chemical_Information_Processing_by_a_Responsive_Chemical_System/24990476 |
| DOI: | 10.1021/jacs.3c11414.s001 |
| الاتاحة: | https://doi.org/10.1021/jacs.3c11414.s001 https://figshare.com/articles/journal_contribution/Chemical_Information_Processing_by_a_Responsive_Chemical_System/24990476 |
| Rights: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.F7BE2D63 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1021/jacs.3c11414.s001 |
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