التفاصيل البيبلوغرافية
| العنوان: |
Mango “Ataulfo” peel extract improves metabolic dysregulation in prediabetic Wistar rats |
| المؤلفون: |
AM Preciado-Saldaña, Wall-Medrano Abraham, Jesus Abraham Dominguez-Avila, J. Fernando Ayala-Zavala, Humberto Astiazaran-Garcia, M Montiel-Herrera, Monica A. Villegas-Ochoa, Gustavo A. Gonzalez-Aguilar |
| المساهمون: |
AM Preciado-Saldaña, Wall-Medrano Abraham, Jesus Abraham Dominguez-Avila, J. Fernando Ayala-Zavala, Humberto Astiazaran-Garcia, M Montiel-Herrera, Monica A. Villegas-Ochoa, Gustavo A. Gonzalez-Aguilar |
| سنة النشر: |
2022 |
| مصطلحات موضوعية: |
Mango, Prediabetes, Metabolism, info:eu-repo/classification/cti/3 |
| الوصف: |
The hypoglycemic effect of functional phytochemicals has been evaluated in diabetic rodents but scarcely in its premorbid condition (prediabetes; PD). This study aimed to evaluate a mango (cv. Ataulfo) peel hydroethanolic (20:80) extract (MPE) for in vivo glycemic/lipidemic-normalizing effect and in vitro enzyme inhibitory ( -amylase/ -glucosidase) activity. The polyphenolic MPE (138 mg EAG.g 1, mainly gallic acid and mangiferin) with antioxidant capacity (DPPH 34 mgTE g 1) was fed to PD rats (induction: high-fat diet (60% energy) + single dose streptozotocin (35 mg kg 1), 4 weeks). At the 8th week, fasting glycemia (FG), oral glucose tolerance test, and insulin sensitivity indexes (HOMA-IR, HOMA- ) > blood lipid-normalizing effect were documented as healthy controls > MPE > disease (PD) controls, which was possibly related to the extract’s concentration–response in vitro enzyme inhibitory activity (IC50 0.085 mg mL 1). MPE is a rich source of glucose-lowering phytochemicals for the primary prevention of type 2 diabetes. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| Relation: |
https://doi.org/10.3390/life12040532 |
| DOI: |
10.3390/life12040532 |
| الاتاحة: |
https://doi.org/10.3390/life12040532 |
| Rights: |
info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by-nc/4.0 |
| رقم الانضمام: |
edsbas.F7A7B1EB |
| قاعدة البيانات: |
BASE |