Academic Journal
Increased lysyl oxidase‐like 2 associates with a poor prognosis in non‐small cell lung cancer
| العنوان: | Increased lysyl oxidase‐like 2 associates with a poor prognosis in non‐small cell lung cancer |
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| المؤلفون: | Zhan, Ping, Lv, Xiao‐Jing, Ji, Ya‐Nan, Xie, Haiyan, Yu, Li‐Ke |
| المصدر: | The Clinical Respiratory Journal ; volume 12, issue 2, page 712-720 ; ISSN 1752-6981 1752-699X |
| بيانات النشر: | Wiley |
| سنة النشر: | 2016 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Background Lysyl oxidase‐like 2 (LOXL2) is a member of the lysyl oxidase family and is associated with invasiveness and metastasis in breast cancer. However, its relevance in non‐small cell lung cancer (NSCLC) remained largely unknown. Methods LOXL2 protein levels in a cohort of NSCLC and adjacent normal lung tissues were evaluated and analyzed their clinicopathologic and prognostic significance. Results It was found that cytoplasmic and nuclear LOXL2 levels were higher in lung adenocarcinoma (AD) and squamous cell carcinoma (SCC) tissues than in paired adjacent normal tissues. High LOXL2 levels were associated with p‐TNM stage, and cytoplasmic, but not nuclear, LOXL2 levels were an independent prognostic factor in lung AD and SCC patients. Conclusion These results demonstrate that elevated LOXL2 levels are positively associated with poor prognosis in NSCLC patients. LOXL2 might, therefore, serve as a novel prognostic biomarker and potential therapeutic target in NSCLC patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/crj.12584 |
| الاتاحة: | http://dx.doi.org/10.1111/crj.12584 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fcrj.12584 https://onlinelibrary.wiley.com/doi/pdf/10.1111/crj.12584 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.F785CC26 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/crj.12584 |
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