التفاصيل البيبلوغرافية
| العنوان: |
CD4+ T cell exhaustion markers expression. |
| المؤلفون: |
Meritxell Llorens-Revull (11106250), Maria Isabel Costafreda (11106253), Angie Rico (11106256), Mercedes Guerrero-Murillo (5814959), Maria Eugenia Soria (3226719), Sofía Píriz-Ruzo (11106259), Elena Vargas-Accarino (11106262), Pablo Gabriel-Medina (11106265), Francisco Rodríguez-Frías (5657464), Mar Riveiro-Barciela (605387), Celia Perales (227281), Josep Quer (161069), Silvia Sauleda (9137412), Juan Ignacio Esteban (3226728), Marta Bes (11106268) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Medicine, Microbiology, Cell Biology, Biotechnology, Immunology, Developmental Biology, Cancer, Mental Health, Infectious Diseases, Virology, Space Science, Chemical Sciences not elsewhere classified, hepatitis C infection, TIM, HCV elimination, DAA treatment, CFSE-based proliferation assays, LAG -3 cell-surface expression, ELISPOT, IL -2 cytokines production, IFN, CD 4 phenotype restoration, PD, intracellular cytokine staining, Hepatitis C patients, T cells responses, patients HCV elimination, DAAs therapies |
| الوصف: |
(A) Analysis of the frequencies of PD-1, TIM-3, LAG-3 markers among CD4+ T cells at baseline and FUW12, (N = 25). (B) Percent of PD-1 among CD4+ T cells according to score fibrosis. Non cirrhotic patients (N = 13), liver stiffness < 9.5 KPa; Cirrhotic patients (N = 12), liver stiffness ≥ 9.5 KPa. (C) Percent of CD4+ PD-1+ T cells in treatment-naive patients (N = 15), and in patients with previous IFN-based therapy (PEG-IFN-α + RBV) (N = 10). (D) Percent of CD4+ PD-1+ T cells in treatment-naive patients below 55 (N = 6), in patients below 55 with previous PEG-IFN-α + RBV treatment (N = 6), in treatment-naive patients over 55 (N = 9) and in patients below 55 previously treated with PEG-IFN-α + RBV (N = 4). Statistical significance was determined by nonparametric Wilcoxon signed-rank test and represented by p-value. P < 0.05 was considered statistically significant. |
| نوع الوثيقة: |
still image |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/figure/CD4_T_cell_exhaustion_markers_expression_/14943919 |
| DOI: |
10.1371/journal.pone.0254243.g001 |
| الاتاحة: |
https://doi.org/10.1371/journal.pone.0254243.g001 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.F7734CD9 |
| قاعدة البيانات: |
BASE |