Academic Journal
Investigation of Linum flavum (L.) Hairy Root Cultures for the Production of Anticancer Aryltetralin Lignans
| العنوان: | Investigation of Linum flavum (L.) Hairy Root Cultures for the Production of Anticancer Aryltetralin Lignans |
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| المؤلفون: | Sullivan Renouard, Cyrielle Corbin, Samantha Drouet, Barbara Medvedec, Joël Doussot, Cyril Colas, Benoit Maunit, Avninder S. Bhambra, Eric Gontier, Nathalie Jullian, François Mesnard, Michèle Boitel, Bilal Haider Abbasi, Randolph R. J. Arroo, Eric Lainé, Christophe Hano |
| المصدر: | International Journal of Molecular Sciences, Vol 19, Iss 4, p 990 (2018) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2018 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | aryltetralin lignans, deoxypodophyllotoxin, 6-Methoxy-podophyllotoxin, podophyllotoxin, hairy root, Linum flavum, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Linum flavum hairy root lines were established from hypocotyl pieces using Agrobacterium rhizogenes strains LBA 9402 and ATCC 15834. Both strains were effective for transformation but induction of hairy root phenotype was more stable with strain ATCC 15834. Whereas similar accumulation patterns were observed in podophyllotoxin-related compounds (6-methoxy-podophyllotoxin, podophyllotoxin and deoxypodophyllotoxin), significant quantitative variations were noted between root lines. The influence of culture medium and various treatments (hormone, elicitation and precursor feeding) were evaluated. The highest accumulation was obtained in Gamborg B5 medium. Treatment with methyl jasmonate, and feeding using ferulic acid increased the accumulation of aryltetralin lignans. These results point to the use of hairy root culture lines of Linum flavum as potential sources for these valuable metabolites as an alternative, or as a complement to Podophyllum collected from wild stands. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1422-0067 |
| Relation: | http://www.mdpi.com/1422-0067/19/4/990; https://doaj.org/toc/1422-0067; https://doaj.org/article/d5e89acac6e741abb0d9ee5197178ada |
| DOI: | 10.3390/ijms19040990 |
| الاتاحة: | https://doi.org/10.3390/ijms19040990 https://doaj.org/article/d5e89acac6e741abb0d9ee5197178ada |
| رقم الانضمام: | edsbas.F763E1CF |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14220067 |
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| DOI: | 10.3390/ijms19040990 |