التفاصيل البيبلوغرافية
| العنوان: |
Tricarboxylic Cycle Intermediates in Combination with Calcium Phosphate Chelators and Sodium Bicarbonate Increases eGFR in Patients with Stages 3b, 4 and 5 CKD: A Retrospective Observational Study ; Intermediarios del ciclo de Krebs en combinación con quelantes cálcicos de fósforo y bicarbonato de sodio aumentan la TFGe en pacientes con ERC en estadios 3b, 4 y 5: un estudio retrospectivo observacional |
| المؤلفون: |
Hernández Miramontes, Jorge Antonio, Méndez Durán, Antonio, Hernández Villanueva, Jorge Alberto |
| المصدر: |
Revista Colombiana de Nefrología; Vol. 11 No. 2 (2024): Continuous publication ; Revista Colombiana de Nefrología; Vol. 11 Núm. 2 (2024): Publicación continua ; 2500-5006 ; 2389-7708 ; 10.22265/acnef.11.2 |
| بيانات النشر: |
Asociación Colombiana de Nefrologia e Hipertension Arterial |
| سنة النشر: |
2024 |
| المجموعة: |
Revista Colombiana de Nefrología |
| مصطلحات موضوعية: |
Chronic kidney disease, CKD-EPI, Creatinine, Estimated glomerular filtration rate, TCA, Nephroprotection, enfermedad renal crónica, creatinina, tasa de filtración glomerular estimada, intermediarios del ciclo de Krebs, nefroprotección |
| الوصف: |
Introduction: Currently, the conservative management of chronic kidney disease (CKD) involves treating the primary disease and its consequences, as well as improving altered biochemical markers. Evidence suggests that the key management strategy for slowing down the progression of the disease is nephroprotection. Objective: This study aimed to evaluate the effect of the supply of TCA cycle intermediates in combination with calcium carbonate, calcium lactate, and sodium bicarbonate in patients with CKD. Methodology: A retrospective observational study was undertaken in nephrology and internal medicine clinics in Mexico. The study enrolled patients aged over 18 with stages 3b, 4, and 5 chronic kidney disease (CKD) who were not undergoing renal replacement therapy (RRT) and had received treatment based on TCA therapy. Results: The study included a total of 55 patients with CKD. The results showed an increase in eGFR from a baseline average of 16.73 ± 1,374 mL/min to a final average of 19.18 ± 1,516 mL/min and a decrease in creatinine values from a baseline average of 4.26 ± 2.44 mg/dL to a final average of 3.77 ± 2.23 mg/dL. These changes had a statistical significance P?0.05.Conclusions: The observed benefits of TCA in combination with sodium bicarbonate, calcium carbonate, and calcium lactate include: 1) Increased eGFR, 2) Decreased serum creatinine, 3) Decreased serum urea, 4) Decreased serum phosphorus, 5) Increased serum hemoglobin, and 6) Maintenance of albumin levels within normal ranges. Adjuvant therapy with the combination of TCA could be a useful tool as a new therapeutic option in patients with CKD. ; Introducción: en la actualidad, el tratamiento de la enfermedad renal crónica (ERC) consiste en tratar la enfermedad primaria y sus consecuencias, así como mejorar los marcadores bioquímicos alterados. Sin embargo, la nefroprotección es clave para retrasar la progresión de la enfermedad. Objetivo: este estudio evalúa el efecto del suministro de intermediarios del ciclo de Krebs en combinación con carbonato ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
https://revistanefrologia.org/index.php/rcn/article/view/778/1115; https://revistanefrologia.org/index.php/rcn/article/view/778 |
| الاتاحة: |
https://revistanefrologia.org/index.php/rcn/article/view/778 |
| Rights: |
http://creativecommons.org/licenses/by-nc-nd/4.0 |
| رقم الانضمام: |
edsbas.F71D8203 |
| قاعدة البيانات: |
BASE |