Academic Journal
Myopic Macular Hole and Detachment after Gene Therapy in Atypical RPE65 Retinal Dystrophy: A Case Report
| العنوان: | Myopic Macular Hole and Detachment after Gene Therapy in Atypical RPE65 Retinal Dystrophy: A Case Report |
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| المؤلفون: | Fabrizio Giansanti, Cristina Nicolosi, Dario Giorgio, Andrea Sodi, Dario Pasquale Mucciolo, Laura Pavese, Liliana Pollazzi, Gianni Virgili, Giulio Vicini, Ilaria Passerini, Elisabetta Pelo, Vittoria Murro |
| المصدر: | Genes, Vol 15, Iss 7, p 879 (2024) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | retinitis pigmentosa, voretigene neparvovec, macular hole, RPE65, gene therapy, complications, Genetics, QH426-470 |
| الوصف: | Purpose: To report a case of macular hole and detachment occurring after the subretinal injection of Voretigene Neparvovec (VN) in a patient affected by atypical RPE65 retinal dystrophy with high myopia and its successful surgical management. Case description: We report a case of a 70-year-old man treated with VN in both eyes. The best corrected visual acuity (BCVA) was 0.7 LogMar in the right eye (RE) and 0.92 LogMar in the left eye (LE). Axial length was 29.60 mm in the RE and 30.28 mm in the LE. Both eyes were pseudophakic. In both eyes, fundus examination revealed high myopia, posterior staphyloma, and extended retinal atrophy areas at the posterior pole, circumscribing a central island of surviving retina. Both eyes were treated with VN subretinal injection, but a full-thickness macular hole and retinal detachment occurred in the LE three weeks after surgery. The patient underwent 23-gauge vitrectomy with internal limiting membrane (ILM) peeling and the inverted flap technique with sulfur hexafluoride (SF6) 20% tamponade. Postoperative follow-up showed that the macular hole was closed and the BCVA was maintained. Conclusions: Our experience suggests that patients with atypical RPE65 retinal dystrophy and high myopia undergoing VN subretinal injection require careful management to minimize the risk of macular hole and detachment occurrence and promptly detect and address these potential complications. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2073-4425 |
| Relation: | https://www.mdpi.com/2073-4425/15/7/879; https://doaj.org/toc/2073-4425; https://doaj.org/article/f21a9e91f54046aa9c99fc07a09c9dbf |
| DOI: | 10.3390/genes15070879 |
| الاتاحة: | https://doi.org/10.3390/genes15070879 https://doaj.org/article/f21a9e91f54046aa9c99fc07a09c9dbf |
| رقم الانضمام: | edsbas.F6FB5D05 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20734425 |
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| DOI: | 10.3390/genes15070879 |