Academic Journal
Impaired cholinergic integrity of the colon and pancreas in dementia with Lewy bodies
| العنوان: | Impaired cholinergic integrity of the colon and pancreas in dementia with Lewy bodies |
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| المؤلفون: | Okkels, Niels, Horsager, Jacob, Fedorova, Tatyana D., Knudsen, Karoline, Skjærbæk, Casper, Andersen, Katrine B., Labrador-Espinosa, Miguel, Vestergaard, Karsten, Mortensen, Janne K., Klit, Henriette, Møller, Mette, Danielsen, Erik H., Johnsen, Erik L., Bekan, Goran, Hansen, Kim V., Munk, Ole L., Damholdt, Malene F., Kjeldsen, Pernille L., Hansen, Allan K, Gottrup, Hanne, Grothe, Michel J., Borghammer, Per |
| المصدر: | Okkels , N , Horsager , J , Fedorova , T D , Knudsen , K , Skjærbæk , C , Andersen , K B , Labrador-Espinosa , M , Vestergaard , K , Mortensen , J K , Klit , H , Møller , M , Danielsen , E H , Johnsen , E L , Bekan , G , Hansen , K V , Munk , O L , Damholdt , M F , Kjeldsen , P L , Hansen , A K , Gottrup , H , Grothe , M J & Borghammer , P 2024 .... |
| سنة النشر: | 2024 |
| المجموعة: | Aalborg University (AAU): Publications / Aalborg Universitet: Publikationer |
| مصطلحات موضوعية: | Aged, Autonomic Nervous System Diseases/diagnostic imaging, Cholinergic Agents, Colon/pathology, Cross-Sectional Studies, Female, Humans, Lewy Body Disease/diagnostic imaging, Male, Pancreas/pathology, autonomic nervous system, PET imaging, Lewy body disease, cholinergic neurons, VAChT proteins |
| الوصف: | Dementia with Lewy bodies is characterized by a high burden of autonomic dysfunction and Lewy pathology in peripheral organs and components of the sympathetic and parasympathetic nervous system. Parasympathetic terminals may be quantified with 18 F-fluoroetoxybenzovesamicol, a PET tracer that binds to the vesicular acetylcholine transporter in cholinergic presynaptic terminals. Parasympathetic imaging may be useful for diagnostics, improving our understanding of autonomic dysfunction and for clarifying the spatiotemporal relationship of neuronal degeneration in prodromal disease. Therefore, we aimed to investigate the cholinergic parasympathetic integrity in peripheral organs and central autonomic regions of subjects with dementia with Lewy bodies and its association with subjective and objective measures of autonomic dysfunction. We hypothesized that organs with known parasympathetic innervation, especially the pancreas and colon, would have impaired cholinergic integrity. To achieve these aims, we conducted a cross-sectional comparison study including 23 newly diagnosed non-diabetic subjects with dementia with Lewy bodies (74 ± 6 years, 83% male) and 21 elderly control subjects (74 ± 6 years, 67% male). We obtained whole-body images to quantify PET uptake in peripheral organs and brain images to quantify PET uptake in regions of the brainstem and hypothalamus. Autonomic dysfunction was assessed with questionnaires and measurements of orthostatic blood pressure. Subjects with dementia with Lewy bodies displayed reduced cholinergic tracer uptake in the pancreas (32% reduction, P = 0.0003) and colon (19% reduction, P = 0.0048), but not in organs with little or no parasympathetic innervation. Tracer uptake in a region of the medulla oblongata overlapping the dorsal motor nucleus of the vagus correlated with autonomic symptoms (r s = -0.54, P = 0.0077) and changes in orthostatic blood pressure (r s = 0.76, P < 0.0001). Tracer uptake in the pedunculopontine region correlated with autonomic symptoms (r s = -0.52, ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1093/brain/awad391 |
| الاتاحة: | https://vbn.aau.dk/da/publications/2a11b17d-9aeb-4ca9-8341-547d8ef77aa3 https://doi.org/10.1093/brain/awad391 https://vbn.aau.dk/ws/files/603318308/Okkels_et_al._2023_._Impaired_cholinergic_integrity_of_the_colon_and_pancreas_in_dementia_with_Lewy_bodies.pdf http://www.scopus.com/inward/record.url?scp=85181852553&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.F6AAB675 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/brain/awad391 |
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