Academic Journal
Detection of retinal and blood Aβ oligomers with nanobodies
| العنوان: | Detection of retinal and blood Aβ oligomers with nanobodies |
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| المؤلفون: | Habiba, Umma (S34411), Descallar, Joseph, Kreilaus, Fabian (R18953), Adhikari, Utpal Kumar (S34370), Kumar, Sachin (S35065), Morley, John W. (R12018), Bui, Bang V., Koronyo-Hamaoui, Maya, Tayebi, Mourad (R19139) |
| بيانات النشر: | U.S., John Wiley & Sons |
| سنة النشر: | 2021 |
| المجموعة: | University of Western Sydney (UWS): Research Direct |
| مصطلحات موضوعية: | XXXXXX - Unknown |
| الوصف: | Introduction: Abnormal retinal changes are increasingly recognized as an early pathological change in Alzheimer’s disease (AD). Although amyloid beta oligomers (Aβo) have been shown to accumulate in the blood and retina of AD patients and animals, it is not known whether the early Aβo deposition precedes their accumulation in brain. Methods and results: Using nanobodies targeting Aβ1-40 and Aβ1-42 oligomers we were able to detect Aβ oligomers in the retina and blood but not in the brain of 3-month-old APP/PS1 mice. Furthermore, Aβ plaques were detected in the brain but not the retina of 3-month-old APP/PS1 mice. Conclusion: These results suggest that retinal accumulation of Aβo originates from peripheral blood and precedes cognitive decline and Aβo deposition in the brain. This provides a very strong basis to develop and implement an “eye test” for early detection of AD using nanobodies targeting retinal Aβ. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | |
| اللغة: | English |
| Relation: | Alzheimer's and Dementia--2352-8729-- Vol. 13 Issue. 1 No. e12193 pp: - |
| DOI: | 10.1002/dad2.12193 |
| الاتاحة: | https://doi.org/10.1002/dad2.12193 https://hdl.handle.net/1959.7/uws:60849 |
| Rights: | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. © 2021 The Authors. Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer’s Association |
| رقم الانضمام: | edsbas.F69B83D3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/dad2.12193 |
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