Academic Journal
MDM2 Copy Numbers in Well-Differentiated and Dedifferentiated Liposarcoma
| العنوان: | MDM2 Copy Numbers in Well-Differentiated and Dedifferentiated Liposarcoma |
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| المؤلفون: | Ware, Patrick L., Snow, Anthony N., Gvalani, Maya, Pettenati, Mark J., Qasem, Shadi A. |
| المصدر: | American Journal of Clinical Pathology ; volume 141, issue 3, page 334-341 ; ISSN 1943-7722 0002-9173 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2014 |
| الوصف: | Objectives: MDM2 gene amplification is associated with well-differentiated (WDL) and dedifferentiated liposarcomas (DDL). Using fluorescent in situ hybridization (FISH), we sought to characterize various patterns of MDM2 amplification among the morphologic spectrum of liposarcoma. Methods: Forty-six cases of liposarcoma in various sites were examined and included 22 WDLs, 14 DLLs, and 10 negative control subjects. Results: The MDM2 amplification ratio (MDM2/CEP12) was lower in WDL (10.2) compared with DDL (18.3) cases (P = .0000002). An amplification ratio of 16 showed optimal sensitivity (0.86) and specificity (0.96) as a cutoff point for progression to DDL. Borderline areas, defined as tumors with increased cellularity and atypia but with preserved lipomatous differentiation, showed a significantly higher MDM2 ratio (17.5; P = .0007) compared with WDL. Central (retroperitoneal and intra-abdominal) tumors also showed a significantly higher MDM2 ratio than peripheral ones (P = .02). Conclusions: Differences in MDM2 amplification profiles among liposarcomas could help further define and predict progression to high-grade neoplasia. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1309/ajcplyu89xhsnhqo |
| الاتاحة: | http://dx.doi.org/10.1309/ajcplyu89xhsnhqo https://academic.oup.com/ajcp/article-pdf/141/3/334/48795607/ajcp_141_3_334.pdf |
| رقم الانضمام: | edsbas.F6675536 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1309/ajcplyu89xhsnhqo |
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