Review
Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas : expert recommendations from the World Sarcoma Network
| العنوان: | Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas : expert recommendations from the World Sarcoma Network |
|---|---|
| المؤلفون: | Demetri, G. D., Antonescu, C. R., Bjerkehagen, B., Bovee, J. V. M. G., Boye, K., Chacon, M., Dei Tos, A. P., Desai, J., Fletcher, J. A., Gelderblom, H., George, S., Gronchi, A., Haas, R. L., Hindi, N., Hohenberger, P., Joensuu, H., Jones, R. L., Judson, Ian, Kang, Y-K, Kawai, A., Lazar, A. J., Le Cesne, A., Maestro, R., Maki, Rg, Martin, J., Patel, S., Penault-Llorca, F., Raut, C. Premanand, Rutkowski, P., Safwat, A., Sbaraglia, M., Schaefer, I-M, Shen, L., Serrano, C., Schoffski, P., Stacchiotti, S., Hall, K. Sundby, Tap, W. D., Thomas, D. M., Trent, J., Valverde, C., van der Graaf, W. T. A., von Mehren, M., Wagner, A., Wardelmann, E., Naito, Y., Zalcberg, J., Blay, J-Y |
| المساهمون: | Research Programs Unit, Heikki Joensuu / Principal Investigator, HUS Comprehensive Cancer Center, Department of Oncology, Clinicum, Helsinki University Hospital Area |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2020 |
| المجموعة: | Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: | entrectinib, larotrectinib, neurotrophic tyrosine receptor kinase, sarcoma, tropomyosin receptor kinase, GASTROINTESTINAL STROMAL TUMORS, ETV6-NTRK3 GENE FUSION, POSITIVE SOLID TUMORS, NTRK FUSION, CONGENITAL INSENSITIVITY, GROWTH-FACTOR, MUTATIONS, CANCERS, SUBSET |
| الوصف: | Sarcomas are a heterogeneous group of malignancies with mesenchymal lineage differentiation. The discovery of neurotrophic tyrosine receptor kinase (NTRK) gene fusions as tissue-agnostic oncogenic drivers has led to new personalized therapies for a subset of patients with sarcoma in the form of tropomyosin receptor kinase (TRK) inhibitors. NTRK gene rearrangements and fusion transcripts can be detected with different molecular pathology techniques, while TRK protein expression can be demonstrated with immunohistochemistry. The rarity and diagnostic complexity of NTRK gene fusions raise a number of questions and challenges for clinicians. To address these challenges, the World Sarcoma Network convened two meetings of expert adult oncologists and pathologists and subsequently developed this article to provide practical guidance on the management of patients with sarcoma harboring NTRK gene fusions. We propose a diagnostic strategy that considers disease stage and histologic and molecular subtypes to facilitate routine testing for TRK expression and subsequent testing for NTRK gene fusions. ; Peer reviewed |
| نوع الوثيقة: | review |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | GDD was supported in part by the Ludwig Center at Harvard; the Dr Miriam and Sheldon G. Adelson Medical Research Foundation; and the Pan Mass Challenge (no grant numbers). IMS is supported by the National Institutes of Health/National Cancer Institute (grant number K08 CA241085). JYB was supported by NetSARC (INCA & DGOS) and RREPS (INCA & DGOS), RESOS (INCA & DGOS), EURACAN (EC 739521), LYRICAN (INCA-DGOS-INSERM 12563), LabEx DEvweCAN (ANR-10-LABX-0061), Institut Convergence PLASCAN (17CONV-0002), RHU4 DEPGYN (ANR-18-RHUS-0009).; Demetri , G D , Antonescu , C R , Bjerkehagen , B , Bovee , J V M G , Boye , K , Chacon , M , Dei Tos , A P , Desai , J , Fletcher , J A , Gelderblom , H , George , S , Gronchi , A , Haas , R L , Hindi , N , Hohenberger , P , Joensuu , H , Jones , R L , Judson , I , Kang , Y-K , Kawai , A , Lazar , A J , Le Cesne , A , Maestro , R , Maki , R , Martin , J , Patel , S , Penault-Llorca , F , Raut , C P , Rutkowski , P , Safwat , A , Sbaraglia , M , Schaefer , I-M , Shen , L , Serrano , C , Schoffski , P , Stacchiotti , S , Hall , K S , Tap , W D , Thomas , D M , Trent , J , Valverde , C , van der Graaf , W T A , von Mehren , M , Wagner , A , Wardelmann , E , Naito , Y , Zalcberg , J & Blay , J-Y 2020 , ' Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas : expert recommendations from the World Sarcoma Network ' , Annals of Oncology , vol. 31 , no. 11 , pp. 1506-1517 . https://doi.org/10.1016/j.annonc.2020.08.2232; ORCID: /0000-0003-0281-2507/work/84255589; http://hdl.handle.net/10138/321873; b9349fb6-a886-49a4-9e24-9cc9773e006d; 000582637200010 |
| الاتاحة: | http://hdl.handle.net/10138/321873 |
| Rights: | cc_by ; info:eu-repo/semantics/openAccess ; openAccess |
| رقم الانضمام: | edsbas.F65B7DC3 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |