Academic Journal

Clinical and peculiar immunological manifestations of SARS-CoV-2 infection in systemic lupus erythematosus patients

التفاصيل البيبلوغرافية
العنوان: Clinical and peculiar immunological manifestations of SARS-CoV-2 infection in systemic lupus erythematosus patients
المؤلفون: Schioppo, Tommaso, Argolini, Lorenza Maria, Sciascia, Savino, Pregnolato, Francesca, Tamborini, Francesco, Miraglia, Paolo, Roccatello, Dario, Sinico, Renato Alberto, Caporali, Roberto, Moroni, Gabriella, Gerosa, Maria
المساهمون: T. Schioppo, L.M. Argolini, S. Sciascia, F. Pregnolato, F. Tamborini, P. Miraglia, D. Roccatello, R.A. Sinico, R. Caporali, G. Moroni, M. Gerosa
بيانات النشر: OXFORD UNIV PRESS
سنة النشر: 2022
المجموعة: The University of Milan: Archivio Istituzionale della Ricerca (AIR)
مصطلحات موضوعية: COVID-19, SARS-CoV-2 infection, Systemic lupus erythematou, disease activity, flare, Settore MED/16 - Reumatologia
الوصف: Objectives The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in patients with SLE remains unclear and data on clinical manifestations after infection are lacking. The aim of this multicentre study is to describe the effect of SARS-CoV-2 in SLE patients. Methods SLE patients referring to four Italian centres were monitored between February 2020 and March 2021. All patients with SARS-CoV-2 infection were included. Disease characteristics, treatment, disease activity and SARS-CoV-2-related symptoms were recorded before and after the infection. Results Fifty-one (6.14%) SLE patients were included among 830 who were regularly followed up. Nine (17.6%) had an asymptomatic infection and 5 (9.8%) out of 42 (82.6%) symptomatic patients developed interstitial pneumonia (no identified risk factor). The presence of SLE major organ involvement (particularly renal involvement) was associated with asymptomatic SARS-CoV-2 infection (P = 0.02). Chronic corticosteroid therapy was found to be associated with asymptomatic infection (P = 0.018). Three SLE flares (5.9%) were developed after SARS-CoV-2 infection: one of them was characterized by MPO-ANCA-positive pauci-immune crescentic necrotizing glomerulonephritis and granulomatous pneumonia. Conclusions SARS-CoV-2 infection determined autoimmune flares in a small number of patients. Our data seem to confirm that there was not an increased risk of SARS-CoV-2 in SLE. Patients with asymptomatic SARS-CoV-2 infections were those having major SLE organ involvement. This may be explained by the high doses of corticosteroids and immunosuppressive agents used for SLE treatment.
نوع الوثيقة: article in journal/newspaper
اللغة: English
Relation: info:eu-repo/semantics/altIdentifier/pmid/34352079; info:eu-repo/semantics/altIdentifier/wos/WOS:000756402000001; volume:61; issue:5; firstpage:1928; lastpage:1935; numberofpages:8; journal:RHEUMATOLOGY; https://hdl.handle.net/2434/919613; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85117351308
DOI: 10.1093/rheumatology/keab611
الاتاحة: https://hdl.handle.net/2434/919613
https://doi.org/10.1093/rheumatology/keab611
Rights: info:eu-repo/semantics/openAccess
رقم الانضمام: edsbas.F64A8EC7
قاعدة البيانات: BASE
الوصف
DOI:10.1093/rheumatology/keab611