Academic Journal
Decreased Glucocorticoid Signaling Potentiates Lipid-Induced Inflammation and Contributes to Insulin Resistance in the Skeletal Muscle of Fructose-Fed Male Rats Exposed to Stress
| العنوان: | Decreased Glucocorticoid Signaling Potentiates Lipid-Induced Inflammation and Contributes to Insulin Resistance in the Skeletal Muscle of Fructose-Fed Male Rats Exposed to Stress |
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| المؤلفون: | Shirif, Abdulbaset Zidane, Kovačević, Sanja, Brkljačić, Jelena, Teofilović, Ana, Elaković, Ivana, Đorđević, Ana, Matić, Gordana |
| المصدر: | International Journal of Molecular Sciences, Special Issue Glucocorticoids and Metabolic Disorders |
| بيانات النشر: | MDPI |
| سنة النشر: | 2021 |
| المجموعة: | RADaR - Digital Repository of Archived Publications Institute for Biological Research "Sinisa Stankovic" / РАДаР - Репозиторијум Архивираних Дигиталних Радова Институт за биолошка истраживања "Синиша Станковић" |
| مصطلحات موضوعية: | fructose, chronic stress, skeletal muscle, glucocorticoids, insulin, lipid metabolism |
| الوصف: | The modern lifestyle brings both excessive fructose consumption and daily exposure to stress which could lead to metabolic disturbances and type 2 diabetes. Muscles are important points of glucose and lipid metabolism, with a crucial role in the maintenance of systemic energy homeostasis. We investigated whether 9-week fructose-enriched diet, with and without exposure to 4- week unpredictable stress, disturbs insulin signaling in the skeletal muscle of male rats and evaluated potential contributory roles of muscle lipid metabolism, glucocorticoid signaling and inflammation. The combination of fructose-enriched diet and stress increased peroxisome proliferator-activated receptors- and - and stimulated lipid uptake, lipolysis and -oxidation in the muscle of fructosefed stressed rats. Combination of treatment also decreased systemic insulin sensitivity judged by lower R-QUICKI, and lowered muscle protein content and stimulatory phosphorylations of insulin receptor supstrate-1 and Akt, as well as the level of 11 -hydroxysteroid dehydrogenase type 1 and glucocorticoid receptor. At the same time, increased levels of protein tyrosine phosphatase-1B, nuclear factor- B, tumor necrosis factor- , were observed in the muscle of fructose-fed stressed rats. Based on these results, we propose that decreased glucocorticoid signaling in the skeletal muscle can make a setting for lipid-induced inflammation and the development of insulin resistance in fructose-fed stressed rats. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1422-0067 |
| Relation: | info:eu-repo/grantAgreement/MESTD/inst-2020/200007/RS//; Swiss National Science Foundation, Grant SCOPES JRP IZ73Z0_152331; https://radar.ibiss.bg.ac.rs/handle/123456789/4259; 2-s2.0-85108973513; 000671173200001; https://radar.ibiss.bg.ac.rs/bitstream/id/8569/ijms-22-07206.pdf |
| DOI: | 10.3390/ijms22137206 |
| الاتاحة: | https://radar.ibiss.bg.ac.rs/handle/123456789/4259 https://doi.org/10.3390/ijms22137206 https://radar.ibiss.bg.ac.rs/bitstream/id/8569/ijms-22-07206.pdf |
| Rights: | openAccess ; https://creativecommons.org/licenses/by/4.0/ ; BY ; © 2021 the authors |
| رقم الانضمام: | edsbas.F6492699 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14220067 |
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| DOI: | 10.3390/ijms22137206 |