Academic Journal
Multirate delivery of multiple therapeutic agents from metal-organic frameworks
| العنوان: | Multirate delivery of multiple therapeutic agents from metal-organic frameworks |
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| المؤلفون: | McKinlay, Alistair Craig, Allan, Phoebe, Renouf, Catherine Louise, Duncan, Morven Jane, Wheatley, Paul Stewart, Warrender, Stewart James, Dawson, Daniel McLean, Ashbrook, Sharon Elizabeth, Gil, Barbara, Marszalek, Bartosz, Düren, Tina, Williams, Jennifer J., Charrier, Cedric, Mercer, Derry K., Teat, Simon J., Morris, Russell Edward |
| المصدر: | McKinlay , A C , Allan , P , Renouf , C L , Duncan , M J , Wheatley , P S , Warrender , S J , Dawson , D M , Ashbrook , S E , Gil , B , Marszalek , B , Düren , T , Williams , J J , Charrier , C , Mercer , D K , Teat , S J & Morris , R E 2014 , ' Multirate delivery of multiple therapeutic agents from metal-organic frameworks ' , APL Materials , vol. 2 , no. 12 , 124108 . .... |
| سنة النشر: | 2014 |
| الوصف: | The highly porous nature of metal-organic frameworks (MOFs) offers great potential for the delivery of therapeutic agents. Here, we show that highly porous metal-organic frameworks can be used to deliver multiple therapeutic agents—a biologically active gas, an antibiotic drug molecule, and an active metal ion—simultaneously but at different rates. The possibilities offered by delivery of multiple agents with different mechanisms of action and, in particular, variable timescales may allow new therapy approaches. Here, we show that the loaded MOFs are highly active against various strains of bacteria. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://research-portal.st-andrews.ac.uk/en/researchoutput/multirate-delivery-of-multiple-therapeutic-agents-from-metalorganic-frameworks(4a726a68-485c-4b46-9b07-30cc210e37bb).html |
| DOI: | 10.1063/1.4903290 |
| الاتاحة: | https://research-portal.st-andrews.ac.uk/en/researchoutput/multirate-delivery-of-multiple-therapeutic-agents-from-metalorganic-frameworks(4a726a68-485c-4b46-9b07-30cc210e37bb).html https://doi.org/10.1063/1.4903290 https://research-repository.st-andrews.ac.uk/bitstream/10023/5913/3/Morris_2014_APlMat_Multirate.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.F62D0A39 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1063/1.4903290 |
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