Academic Journal

International and multicenter real-world study of sorafenib-treated patients with hepatocellular carcinoma under dialysis

التفاصيل البيبلوغرافية
العنوان: International and multicenter real-world study of sorafenib-treated patients with hepatocellular carcinoma under dialysis
المؤلفون: Díaz-González, Álvaro, Sanduzzi-Zamparelli, Marco, Gomes da Fonseca, L Leonardo, Di Costanzo, Giovan Giuseppe, Alves, Rogerio, Iavarone, Massimo, Leal, Cassia, Sacco, Rodolfo, Matilla, Ana María, Hernández-Guerra, Manuel, Aballay Soteras, Gabriel, Wörns, Marcus-Alexander, Pinter, Matthias, Varela, María, Ladekarl, Morten, Chagas, Aline Lopes, Mínguez, Beatriz, Arenas, Juan Ignacio, Granito, Alessandro, Sánchez-Torrijos, Yolanda, Rojas, Ángela, Rodríguez de Lope, Carlos, Alvares-da-Silva, Mario Reis, Pascual, Sonia, Rimassa, Lorenza, Lledó, José Luis, Huertas, Carlos, Sangro, Bruno, Giannini, Edoardo G, Delgado, Manuel, Vergara, Mercedes, Perelló, Christie, Lue, Alberto, Sala, Margarita, Gallego, Adolfo, Coll, Susanna, Hernáez, Tania, Piñero, Federico, Pereira, Gustavo, França, Alex, Marín, Juan, Anders, Margarita, Mello, Vivianne, Lozano, Mar, Nault, Jean Charles, Menéndez, Josemaría, García Juárez, Ignacio, Bruix, Jordi, Reig, María
المصدر: Díaz-González , Á , Sanduzzi-Zamparelli , M , Gomes da Fonseca , L L , Di Costanzo , G G , Alves , R , Iavarone , M , Leal , C , Sacco , R , Matilla , A M , Hernández-Guerra , M , Aballay Soteras , G , Wörns , M-A , Pinter , M , Varela , M , Ladekarl , M , Chagas , A L , Mínguez , B , Arenas , J I , Granito , A , Sánchez-Torrijos , Y , Rojas , Á , Rodríguez de Lope , C , ....
سنة النشر: 2020
المجموعة: Aalborg University (AAU): Publications / Aalborg Universitet: Publikationer
مصطلحات موضوعية: Hepatocellular carcinoma, adverse events, dialysis, safety, sorafenib, survival
الوصف: Background & Aims: Information on safety and efficacy of systemic treatment in patients with hepatocellular carcinoma (HCC) under dialysis are limited due to patient exclusion from clinical trials. Thus, we aimed to evaluate the rate, prevalence, tolerability, and outcome of sorafenib in this population. Methods: We report a multicenter study comprising patients from Latin America and Europe. Patients treated with sorafenib were enrolled; demographics, dose modifications, adverse events (AEs), treatment duration, and outcome of patients undergoing dialysis were recorded. Results: As of March 2018, 6156 HCC patients were treated in 44 centres and 22 patients were concomitantly under dialysis (0.36%). The median age was 65.5 years, 40.9% had hepatitis C, 75% had Child-Pugh A, and 85% were Barcelona Clinic Liver Cancer-C. The median time to first dose modification, treatment duration and overall survival rate were 2.4 months (interquartile ranges [IQR], 0.8-3.8), 10.8 months (IQR, 4.5-16.9), and 17.5 months (95% CI, 7.2-24.5), respectively. Seventeen patients required at least 1 dose modification. The main causes of first dose modification were asthenia/worsening of Eastern Cooperative Oncology Group-Performance Status and diarrhoea. At the time of death or last follow-up, four patients were still on treatment and 18 had discontinued sorafenib: 14 were due to tumour progression, 2 were sorafenib-related, and 2 were non-sorafenib-related AE. Conclusions: The outcomes observed in this cohort seem comparable to those in the non-dialysis population. Thus, to the best of our knowledge, this is the largest and most informative dataset regarding systemic treatment outcomes in HCC patients undergoing dialysis.
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: English
DOI: 10.1111/liv.14436
الاتاحة: https://vbn.aau.dk/da/publications/6ac48250-c4fd-46ca-b836-6ea01a0df522
https://doi.org/10.1111/liv.14436
https://vbn.aau.dk/ws/files/337446077/International_and_multicenter_real_world_study_of_sorafenib_treated_patients_with_hepatocellular_carcinoma_under_dialysis.pdf
http://www.scopus.com/inward/record.url?scp=85083419935&partnerID=8YFLogxK
Rights: info:eu-repo/semantics/openAccess
رقم الانضمام: edsbas.F5E3640D
قاعدة البيانات: BASE